Prostate cancer susceptibility polymorphism rs2660753 s not associated with invasive ovarian cancer

Ernest Amankwah, Linda E. Kelemen, Qinggang Wang, Honglin Song, Georgia Chenevix-Trench, Jonathan Beesley, Penelope M. Webb, Celeste L. Pearce, Anna H. Wu, Malcolm C. Pike, Daniel O. Stram, Jenny Chang-Claude, Shan Wang-Gohrke, Roberta B. Ness, Ellen L. Goode, Julie M. Cunningham, Brooke L. Fridley, Robert A. Vierkant, Shelley S. Tworoger, Alice S. Whittemore & 24 others Valerie McGuire, Weiva Sieh, Simon A. Gayther, Aleksandra Gentry-Maharaj, Usha Menon, Susan J. Ramus, Mary Anne Rossing, Jennifer A. Doherty, Marc T. Goodman, Michael E. Carney, Galina Lurie, Lynne R. Wilkens, Susanne Kruger Kjær, Estrid Høgdall, Daniel W. Cramer, Kathryn L. Terry, Montserrat Garcia-Closas, Hannah Yang, Jolanta Lissowska, Hoda Anton-Culver, Argyrios Ziogas, Joellen M. Schildkraut, Andrew Berchuck, Paul D P Pharoah

Research output: Contribution to journalArticle

Abstract

Background: We previously reported an association between rs2660753, a prostate cancer susceptibility polymorphism, and invasive epithelial ovarian cancer (EOC; OR = 1.2, 95% CI= 1.0-1.4, Ptrend = 0.01) that showed a stronger association with the serous histological subtype (OR = 1.3, 95% CI = 1.1-1.5, Ptrend = 0.003). Methods: We sought to replicate this association in 12 other studies comprising 4,482 cases and 6,894 controls of white non-Hispanic ancestry in the Ovarian Cancer Association Consortium. Results: No evidence for an association with all cancers or serous cancers was observed in a combined analysis of data from the replication studies (all: OR = 1.0, 95% CI = 0.9-1.1, Ptrend = 0.61; serous: OR = 1.0, 95% CI = 0.9-1.1, Ptrend = 0.85) or from the combined analysis of discovery and replication studies (all: OR = 1.0, 95% CI = 1.0-1.1, Ptrend = 0.28; serous: OR = 1.1, 95% CI = 1.0-1.2, Ptrend = 0.11). There was no evidence for statistical heterogeneity in ORs across the studies. Conclusions: Although rs2660753 is a strong prostate cancer susceptibility polymorphism, the association with another hormonally related cancer, invasive EOC, is not supported by this replication study. Impact: Our findings, based on a larger sample size, emphasize the importance of replicating potentially promising genetic risk associations.

Original languageEnglish (US)
Pages (from-to)1028-1031
Number of pages4
JournalCancer Epidemiology Biomarkers and Prevention
Volume20
Issue number5
DOIs
StatePublished - May 2011
Externally publishedYes

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Ovarian Neoplasms
Prostatic Neoplasms
Neoplasms
Sample Size
Ovarian epithelial cancer

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Prostate cancer susceptibility polymorphism rs2660753 s not associated with invasive ovarian cancer. / Amankwah, Ernest; Kelemen, Linda E.; Wang, Qinggang; Song, Honglin; Chenevix-Trench, Georgia; Beesley, Jonathan; Webb, Penelope M.; Pearce, Celeste L.; Wu, Anna H.; Pike, Malcolm C.; Stram, Daniel O.; Chang-Claude, Jenny; Wang-Gohrke, Shan; Ness, Roberta B.; Goode, Ellen L.; Cunningham, Julie M.; Fridley, Brooke L.; Vierkant, Robert A.; Tworoger, Shelley S.; Whittemore, Alice S.; McGuire, Valerie; Sieh, Weiva; Gayther, Simon A.; Gentry-Maharaj, Aleksandra; Menon, Usha; Ramus, Susan J.; Rossing, Mary Anne; Doherty, Jennifer A.; Goodman, Marc T.; Carney, Michael E.; Lurie, Galina; Wilkens, Lynne R.; Kjær, Susanne Kruger; Høgdall, Estrid; Cramer, Daniel W.; Terry, Kathryn L.; Garcia-Closas, Montserrat; Yang, Hannah; Lissowska, Jolanta; Anton-Culver, Hoda; Ziogas, Argyrios; Schildkraut, Joellen M.; Berchuck, Andrew; Pharoah, Paul D P.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 20, No. 5, 05.2011, p. 1028-1031.

Research output: Contribution to journalArticle

Amankwah, E, Kelemen, LE, Wang, Q, Song, H, Chenevix-Trench, G, Beesley, J, Webb, PM, Pearce, CL, Wu, AH, Pike, MC, Stram, DO, Chang-Claude, J, Wang-Gohrke, S, Ness, RB, Goode, EL, Cunningham, JM, Fridley, BL, Vierkant, RA, Tworoger, SS, Whittemore, AS, McGuire, V, Sieh, W, Gayther, SA, Gentry-Maharaj, A, Menon, U, Ramus, SJ, Rossing, MA, Doherty, JA, Goodman, MT, Carney, ME, Lurie, G, Wilkens, LR, Kjær, SK, Høgdall, E, Cramer, DW, Terry, KL, Garcia-Closas, M, Yang, H, Lissowska, J, Anton-Culver, H, Ziogas, A, Schildkraut, JM, Berchuck, A & Pharoah, PDP 2011, 'Prostate cancer susceptibility polymorphism rs2660753 s not associated with invasive ovarian cancer', Cancer Epidemiology Biomarkers and Prevention, vol. 20, no. 5, pp. 1028-1031. https://doi.org/10.1158/1055-9965.EPI-11-0053
Amankwah, Ernest ; Kelemen, Linda E. ; Wang, Qinggang ; Song, Honglin ; Chenevix-Trench, Georgia ; Beesley, Jonathan ; Webb, Penelope M. ; Pearce, Celeste L. ; Wu, Anna H. ; Pike, Malcolm C. ; Stram, Daniel O. ; Chang-Claude, Jenny ; Wang-Gohrke, Shan ; Ness, Roberta B. ; Goode, Ellen L. ; Cunningham, Julie M. ; Fridley, Brooke L. ; Vierkant, Robert A. ; Tworoger, Shelley S. ; Whittemore, Alice S. ; McGuire, Valerie ; Sieh, Weiva ; Gayther, Simon A. ; Gentry-Maharaj, Aleksandra ; Menon, Usha ; Ramus, Susan J. ; Rossing, Mary Anne ; Doherty, Jennifer A. ; Goodman, Marc T. ; Carney, Michael E. ; Lurie, Galina ; Wilkens, Lynne R. ; Kjær, Susanne Kruger ; Høgdall, Estrid ; Cramer, Daniel W. ; Terry, Kathryn L. ; Garcia-Closas, Montserrat ; Yang, Hannah ; Lissowska, Jolanta ; Anton-Culver, Hoda ; Ziogas, Argyrios ; Schildkraut, Joellen M. ; Berchuck, Andrew ; Pharoah, Paul D P. / Prostate cancer susceptibility polymorphism rs2660753 s not associated with invasive ovarian cancer. In: Cancer Epidemiology Biomarkers and Prevention. 2011 ; Vol. 20, No. 5. pp. 1028-1031.
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title = "Prostate cancer susceptibility polymorphism rs2660753 s not associated with invasive ovarian cancer",
abstract = "Background: We previously reported an association between rs2660753, a prostate cancer susceptibility polymorphism, and invasive epithelial ovarian cancer (EOC; OR = 1.2, 95{\%} CI= 1.0-1.4, Ptrend = 0.01) that showed a stronger association with the serous histological subtype (OR = 1.3, 95{\%} CI = 1.1-1.5, Ptrend = 0.003). Methods: We sought to replicate this association in 12 other studies comprising 4,482 cases and 6,894 controls of white non-Hispanic ancestry in the Ovarian Cancer Association Consortium. Results: No evidence for an association with all cancers or serous cancers was observed in a combined analysis of data from the replication studies (all: OR = 1.0, 95{\%} CI = 0.9-1.1, Ptrend = 0.61; serous: OR = 1.0, 95{\%} CI = 0.9-1.1, Ptrend = 0.85) or from the combined analysis of discovery and replication studies (all: OR = 1.0, 95{\%} CI = 1.0-1.1, Ptrend = 0.28; serous: OR = 1.1, 95{\%} CI = 1.0-1.2, Ptrend = 0.11). There was no evidence for statistical heterogeneity in ORs across the studies. Conclusions: Although rs2660753 is a strong prostate cancer susceptibility polymorphism, the association with another hormonally related cancer, invasive EOC, is not supported by this replication study. Impact: Our findings, based on a larger sample size, emphasize the importance of replicating potentially promising genetic risk associations.",
author = "Ernest Amankwah and Kelemen, {Linda E.} and Qinggang Wang and Honglin Song and Georgia Chenevix-Trench and Jonathan Beesley and Webb, {Penelope M.} and Pearce, {Celeste L.} and Wu, {Anna H.} and Pike, {Malcolm C.} and Stram, {Daniel O.} and Jenny Chang-Claude and Shan Wang-Gohrke and Ness, {Roberta B.} and Goode, {Ellen L.} and Cunningham, {Julie M.} and Fridley, {Brooke L.} and Vierkant, {Robert A.} and Tworoger, {Shelley S.} and Whittemore, {Alice S.} and Valerie McGuire and Weiva Sieh and Gayther, {Simon A.} and Aleksandra Gentry-Maharaj and Usha Menon and Ramus, {Susan J.} and Rossing, {Mary Anne} and Doherty, {Jennifer A.} and Goodman, {Marc T.} and Carney, {Michael E.} and Galina Lurie and Wilkens, {Lynne R.} and Kj{\ae}r, {Susanne Kruger} and Estrid H{\o}gdall and Cramer, {Daniel W.} and Terry, {Kathryn L.} and Montserrat Garcia-Closas and Hannah Yang and Jolanta Lissowska and Hoda Anton-Culver and Argyrios Ziogas and Schildkraut, {Joellen M.} and Andrew Berchuck and Pharoah, {Paul D P}",
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T1 - Prostate cancer susceptibility polymorphism rs2660753 s not associated with invasive ovarian cancer

AU - Amankwah, Ernest

AU - Kelemen, Linda E.

AU - Wang, Qinggang

AU - Song, Honglin

AU - Chenevix-Trench, Georgia

AU - Beesley, Jonathan

AU - Webb, Penelope M.

AU - Pearce, Celeste L.

AU - Wu, Anna H.

AU - Pike, Malcolm C.

AU - Stram, Daniel O.

AU - Chang-Claude, Jenny

AU - Wang-Gohrke, Shan

AU - Ness, Roberta B.

AU - Goode, Ellen L.

AU - Cunningham, Julie M.

AU - Fridley, Brooke L.

AU - Vierkant, Robert A.

AU - Tworoger, Shelley S.

AU - Whittemore, Alice S.

AU - McGuire, Valerie

AU - Sieh, Weiva

AU - Gayther, Simon A.

AU - Gentry-Maharaj, Aleksandra

AU - Menon, Usha

AU - Ramus, Susan J.

AU - Rossing, Mary Anne

AU - Doherty, Jennifer A.

AU - Goodman, Marc T.

AU - Carney, Michael E.

AU - Lurie, Galina

AU - Wilkens, Lynne R.

AU - Kjær, Susanne Kruger

AU - Høgdall, Estrid

AU - Cramer, Daniel W.

AU - Terry, Kathryn L.

AU - Garcia-Closas, Montserrat

AU - Yang, Hannah

AU - Lissowska, Jolanta

AU - Anton-Culver, Hoda

AU - Ziogas, Argyrios

AU - Schildkraut, Joellen M.

AU - Berchuck, Andrew

AU - Pharoah, Paul D P

PY - 2011/5

Y1 - 2011/5

N2 - Background: We previously reported an association between rs2660753, a prostate cancer susceptibility polymorphism, and invasive epithelial ovarian cancer (EOC; OR = 1.2, 95% CI= 1.0-1.4, Ptrend = 0.01) that showed a stronger association with the serous histological subtype (OR = 1.3, 95% CI = 1.1-1.5, Ptrend = 0.003). Methods: We sought to replicate this association in 12 other studies comprising 4,482 cases and 6,894 controls of white non-Hispanic ancestry in the Ovarian Cancer Association Consortium. Results: No evidence for an association with all cancers or serous cancers was observed in a combined analysis of data from the replication studies (all: OR = 1.0, 95% CI = 0.9-1.1, Ptrend = 0.61; serous: OR = 1.0, 95% CI = 0.9-1.1, Ptrend = 0.85) or from the combined analysis of discovery and replication studies (all: OR = 1.0, 95% CI = 1.0-1.1, Ptrend = 0.28; serous: OR = 1.1, 95% CI = 1.0-1.2, Ptrend = 0.11). There was no evidence for statistical heterogeneity in ORs across the studies. Conclusions: Although rs2660753 is a strong prostate cancer susceptibility polymorphism, the association with another hormonally related cancer, invasive EOC, is not supported by this replication study. Impact: Our findings, based on a larger sample size, emphasize the importance of replicating potentially promising genetic risk associations.

AB - Background: We previously reported an association between rs2660753, a prostate cancer susceptibility polymorphism, and invasive epithelial ovarian cancer (EOC; OR = 1.2, 95% CI= 1.0-1.4, Ptrend = 0.01) that showed a stronger association with the serous histological subtype (OR = 1.3, 95% CI = 1.1-1.5, Ptrend = 0.003). Methods: We sought to replicate this association in 12 other studies comprising 4,482 cases and 6,894 controls of white non-Hispanic ancestry in the Ovarian Cancer Association Consortium. Results: No evidence for an association with all cancers or serous cancers was observed in a combined analysis of data from the replication studies (all: OR = 1.0, 95% CI = 0.9-1.1, Ptrend = 0.61; serous: OR = 1.0, 95% CI = 0.9-1.1, Ptrend = 0.85) or from the combined analysis of discovery and replication studies (all: OR = 1.0, 95% CI = 1.0-1.1, Ptrend = 0.28; serous: OR = 1.1, 95% CI = 1.0-1.2, Ptrend = 0.11). There was no evidence for statistical heterogeneity in ORs across the studies. Conclusions: Although rs2660753 is a strong prostate cancer susceptibility polymorphism, the association with another hormonally related cancer, invasive EOC, is not supported by this replication study. Impact: Our findings, based on a larger sample size, emphasize the importance of replicating potentially promising genetic risk associations.

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