Prostate cancer prevention trials in the USA

O. W. Brawley, H. Parnes

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


There is dramatic international variation in prostate cancer mortality rates. The variation suggests that the disease has an environmental cause and encourages the search for a way to prevent it. Androgenic stimulation over a period of time, perhaps due to a high fat diet, has been suggested as a cause of prostate cancer. The corollary to this hypothesis is that lowering androgenic stimulation over time will prevent prostate cancer. 5-Alpha-reductase inhibition through drugs like finasteride have been shown to decrease androgenic stimulation of the prostate. A clinical trial is underway using finasteride to assess this hypothesis. Epidemiological and laboratory studies also suggest that those with high selenium and vitamin E intake have a lower risk of prostate cancer. Recent serendipitous findings of two randomised clinical trials support this. A study to assess these compounds is currently being designed. Other promising but less developed interventions in the chemoprevention of prostate cancer include vitamin D supple-mentation and diet modification.

Original languageEnglish (US)
Pages (from-to)1312-1315
Number of pages4
JournalEuropean Journal of Cancer
Issue number10
StatePublished - Jan 1 2000
Externally publishedYes


  • 5-alpha-reductase inhibitor
  • Alpha tocopherol
  • Chemoprevention
  • Clinical trials
  • Prostate
  • Prostate cancer
  • Selenium

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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