TY - JOUR
T1 - Prostate cancer grading
T2 - a decade after the 2005 modified system
AU - Epstein, Jonathan I.
N1 - Publisher Copyright:
© 2018, United States & Canadian Academy of Pathology USCAP, Inc.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - This review article will cover the evolution of grading of prostate cancer from the original Gleason system in the 1960–1970s to a more patient-centric grading system proposed in 2013 from a group at Johns Hopkins Hospital, validated in 2014 by a large multi-institutional study, and subsequently accepted by the World Health Organization (WHO), College of American Pathology (CAP), and the AJCC TNM system. Covered topics include: (1) historical background; (2) 2005 and 2014 International Society of Urological Pathology Grading Conferences; (3) Description of Gleason patterns; (4) new approaches to display Gleason grades; (5) grading variants and variations of acinar adenocarcinoma; (6) reporting rules for Gleason grading reporting secondary patterns of higher grade when present to a limited extent; (7) reporting secondary patterns of lower grade when present to a limited extent; (8) reporting percentage pattern 4; (9) general applications of the Gleason grading system; (10) needle biopsy with different cores showing different grades; (11) radical prostatectomy specimens with separate tumor nodules; and (12) a new grading system for prostate cancer.
AB - This review article will cover the evolution of grading of prostate cancer from the original Gleason system in the 1960–1970s to a more patient-centric grading system proposed in 2013 from a group at Johns Hopkins Hospital, validated in 2014 by a large multi-institutional study, and subsequently accepted by the World Health Organization (WHO), College of American Pathology (CAP), and the AJCC TNM system. Covered topics include: (1) historical background; (2) 2005 and 2014 International Society of Urological Pathology Grading Conferences; (3) Description of Gleason patterns; (4) new approaches to display Gleason grades; (5) grading variants and variations of acinar adenocarcinoma; (6) reporting rules for Gleason grading reporting secondary patterns of higher grade when present to a limited extent; (7) reporting secondary patterns of lower grade when present to a limited extent; (8) reporting percentage pattern 4; (9) general applications of the Gleason grading system; (10) needle biopsy with different cores showing different grades; (11) radical prostatectomy specimens with separate tumor nodules; and (12) a new grading system for prostate cancer.
UR - http://www.scopus.com/inward/record.url?scp=85049557929&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85049557929&partnerID=8YFLogxK
U2 - 10.1038/modpathol.2017.133
DO - 10.1038/modpathol.2017.133
M3 - Article
C2 - 29297487
AN - SCOPUS:85049557929
SN - 0893-3952
VL - 31
SP - 47
EP - 63
JO - Modern Pathology
JF - Modern Pathology
ER -