Prostate cancer grading: a decade after the 2005 modified system

Research output: Contribution to journalArticle

Abstract

This review article will cover the evolution of grading of prostate cancer from the original Gleason system in the 1960-1970s to a more patient-centric grading system proposed in 2013 from a group at Johns Hopkins Hospital, validated in 2014 by a large multi-institutional study, and subsequently accepted by the World Health Organization (WHO), College of American Pathology (CAP), and the AJCC TNM system. Covered topics include: (1) historical background; (2) 2005 and 2014 International Society of Urological Pathology Grading Conferences; (3) Description of Gleason patterns; (4) new approaches to display Gleason grades; (5) grading variants and variations of acinar adenocarcinoma; (6) reporting rules for Gleason grading reporting secondary patterns of higher grade when present to a limited extent; (7) reporting secondary patterns of lower grade when present to a limited extent; (8) reporting percentage pattern 4; (9) general applications of the Gleason grading system; (10) needle biopsy with different cores showing different grades; (11) radical prostatectomy specimens with separate tumor nodules; and (12) a new grading system for prostate cancer.

Original languageEnglish (US)
Pages (from-to)S47-S63
JournalModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Volume31
Issue numberS1
DOIs
StatePublished - Jan 1 2018

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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