Prostate biopsy: Indications and technique

Brian Matlaga, L. Andrew Eskew, David L. McCullough

Research output: Contribution to journalArticle

Abstract

Purpose: The last decade has seen numerous modifications in the way prostate cancer is diagnosed. We review the current indications for and methods of prostate biopsy. Materials and Methods: The English language literature was reviewed regarding major indications for and methods of prostate biopsy. Pertinent peer reviewed articles were collated and analyzed. Results: The most widely accepted indication for prostate biopsy is a prostate specific antigen (PSA) value of greater than 4.0 ng./ml. However, some investigators advocate prostate biopsy for men with a PSA value in the 2.5 to 4.0 ng./ml. range, believing that use of this parameter results in detection of a greater number of cases of curable disease. Age specific PSA range, percent free PSA and presence of prostatic intraepithelial neoplasia or atypia are all considered to be relative indications for prostate biopsy. The current literature describes a trend toward increasing the number of cores obtained and the sites biopsied beyond those of the standard sextant technique. The additional cores in many series are obtained from more lateral regions of the gland. Conclusions: Although several criteria are used as indications for initial prostate biopsy, all are based on PSA level and/or abnormal digital rectal examination. Future improvements in currently used prostate cancer markers may result in better selection of cases to biopsy. There is no universally accepted technique of prostate gland biopsy. The current literature supports use of more extensive biopsy techniques to increase the likelihood of prostate cancer detection.

Original languageEnglish (US)
Pages (from-to)12-19
Number of pages8
JournalJournal of Urology
Volume169
Issue number1
StatePublished - Jan 1 2003
Externally publishedYes

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Prostate
Biopsy
Prostate-Specific Antigen
Prostatic Neoplasms
Prostatic Intraepithelial Neoplasia
Digital Rectal Examination
Language
Research Personnel

Keywords

  • Biopsy, needle
  • Prostate
  • Prostate-specific antigen
  • Prostatic neoplasms

ASJC Scopus subject areas

  • Urology

Cite this

Matlaga, B., Eskew, L. A., & McCullough, D. L. (2003). Prostate biopsy: Indications and technique. Journal of Urology, 169(1), 12-19.

Prostate biopsy : Indications and technique. / Matlaga, Brian; Eskew, L. Andrew; McCullough, David L.

In: Journal of Urology, Vol. 169, No. 1, 01.01.2003, p. 12-19.

Research output: Contribution to journalArticle

Matlaga, B, Eskew, LA & McCullough, DL 2003, 'Prostate biopsy: Indications and technique', Journal of Urology, vol. 169, no. 1, pp. 12-19.
Matlaga B, Eskew LA, McCullough DL. Prostate biopsy: Indications and technique. Journal of Urology. 2003 Jan 1;169(1):12-19.
Matlaga, Brian ; Eskew, L. Andrew ; McCullough, David L. / Prostate biopsy : Indications and technique. In: Journal of Urology. 2003 ; Vol. 169, No. 1. pp. 12-19.
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