Prostanoids and pain: Unraveling mechanisms and revealing therapeutic targets

Tarek A. Samad, Adam Sapirstein, Clifford J. Woolf

Research output: Contribution to journalReview articlepeer-review

Abstract

Advances in our understanding of the synthesis, regulation and function of prostanoids have led to a new appreciation of their actions in health and disease. Prostanoid synthesis is essential for the generation of inflammatory pain and this depends not only on prostanoid production at the site of inflammation, but also on the actions of prostanoids synthesized within the central nervous system (CNS). Moreover, central prostanoid synthesis is controlled both by neural and humoral signals, the latter being a novel form of input to the CNS. Diverse compounds that act along the pathway of prostanoid synthesis and action, both in the periphery and in the CNS, might provide increased benefit for treating inflammatory pain hypersensitivity and its associated sickness syndrome, with a reduced risk of adverse effects.

Original languageEnglish (US)
Pages (from-to)390-396
Number of pages7
JournalTrends in Molecular Medicine
Volume8
Issue number8
DOIs
StatePublished - 2002
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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