Prostaglandins and estradiol-induced attenuation of hypoxic pulmonary vasoconstriction

J. T. Sylvester, J. B. Gordon, R. L. Malamet, R. C. Wetzel

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Abstract

Pretreatment with estradiol (20 mg IM) attenuated vasoreactivity to decreases in inspired PIO2 lowered baseline resistance measured under conditions of maximal vasodilation (PIO2 = 0 mm Hg), and appeared to increase prostaglandin release in isolated, blood-perfused lungs of juvenile female sheep. Indomethacin (40 μg/ml) inhibited prostaglandin release and restored hypoxic vasoreactivity in estrogen-treated lungs, but did not alter the estrogen-induced decrease in baseline resistance. These results suggest that estradiol enhanced the production of prostaglandins which secondarily attenuated hypoxic vasoreactivity. The estradiol-induced decrease in baseline resistance, however, must have been mediated by some other mechanism.

Original languageEnglish (US)
JournalChest
Volume88
Issue number4 SUPPL.
Publication statusPublished - 1985

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ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Sylvester, J. T., Gordon, J. B., Malamet, R. L., & Wetzel, R. C. (1985). Prostaglandins and estradiol-induced attenuation of hypoxic pulmonary vasoconstriction. Chest, 88(4 SUPPL.).