Prostaglandin f metabolite concentration as a prognostic factor in preterm labor

Claire M. Weitz, Ramesh B. Ghodgaonkar, Norman H. Dubin, Jennifer R. Niebyl

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Concentration of the 13,14-dihydro,15 keto-metabolite of prostaglandin F2[alpha] (PGFM) was measured in women being observed for preterm labor. The mean initial PGFM level was significantly higher in patients who delivered preterm (65.9 +/- 9.7 pg/mL; N=14) than in patients not in preterm labor (32.1 +/- 4.3 pg/mL; N=11; P<.01). Plasma PGFM concentrations decreased significantly during ritodrine therapy only in successfully treated patients (P<.05). All patients with initial PGFM concentrations greater than or equal to 55 pg/mL delivered preterm. Two of four patients not considered to be in preterm labor but who delivered prematurely (within five days of initial evaluation) had initial PGFM concentrations of greater than 55 pg/mL. Concentration determinations of PGFM might be a useful adjunct in identifying early preterm labor and in predicting success of tocolytic therapy.

Original languageEnglish (US)
Pages (from-to)496-499
Number of pages4
JournalObstetrics and gynecology
Volume67
Issue number4
StatePublished - Apr 1986

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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