Prospects for primary stroke prevention in children with sickle cell anaemia

Lori C. Jordan, James F. Casella, Michael R. Debaun

Research output: Contribution to journalReview articlepeer-review

Abstract

This review will focus on the strengths and limitations associated with the current standard of care for primary prevention of ischaemic strokes in children with sickle cell anaemia (SCA) - transcranial Doppler ultrasound (TCD) screening followed by regular blood transfusion therapy when TCD measurement is above a threshold defined by a randomized clinical trial (RCT). The theoretical basis for potential alternative strategies for primary prevention of neurological injury in SCA is also discussed. These strategies will include, but will not be limited to: immunizations to prevent bacterial infections, particularly in low income countries; management of elevated blood pressure; and targeted strategies to increase baseline haemoglobin levels with therapies such as hyroxycarbamide or potentially definitive haematopoietic stem cell transplant.

Original languageEnglish (US)
Pages (from-to)14-25
Number of pages12
JournalBritish journal of haematology
Volume157
Issue number1
DOIs
StatePublished - Apr 2012

Keywords

  • Child
  • Primary prevention
  • Sickle cell anaemia
  • Stroke
  • Treatment

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Prospects for primary stroke prevention in children with sickle cell anaemia'. Together they form a unique fingerprint.

Cite this