Prospects for oral replicating adenovirus-vectored vaccines

Research output: Contribution to journalReview articlepeer-review

Abstract

Orally delivered replicating adenovirus (Ad) vaccines have been used for decades to prevent adenovirus serotype 4 and 7 respiratory illness in military recruits, demonstrating exemplary safety and high efficacy. That experience suggests that oral administration of live recombinant Ads (rAds) holds promise for immunization against other infectious diseases, including those that have been refractory to traditional vaccination methods. Live rAds can express intact antigens from free-standing transgenes during replication in infected cells. Alternatively, antigenic epitopes can be displayed on the rAd capsid itself, allowing presentation of the epitope to the immune system both prior to and during replication of the virus. Such capsid-display rAds offer a novel vaccine approach that could be used either independently of or in combination with transgene expression strategies to provide a new tool in the search for protection from infectious disease.

Original languageEnglish (US)
Pages (from-to)3236-3243
Number of pages8
JournalVaccine
Volume31
Issue number32
DOIs
StatePublished - Jun 10 2013

Keywords

  • Capsid-display
  • Hexon
  • Oral administration
  • Replicating adenovirus vectors
  • Vaccine

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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