Prospects for development of a rotavirus vaccine against rotavirus diarrhea in infants and young children

Albert Z. Kapikian; Jorge Flores; Yasutaka Hoshino; Karen Midthun; Mario Gorziglia; Kim Y. Green; Robert M. Chanock; Louis Potash; Stephen D. Sears; Mary Lou Clements; Neal A. Halsey; Robert E. Black; Irene Perez-Schael

doi:10.1093/clinids/11.Supplement_3.S539

Prospects for development of a rotavirus vaccine against rotavirus diarrhea in infants and young children

Albert Z. Kapikian, Jorge Flores, Yasutaka Hoshino, Karen Midthun, Mario Gorziglia, Kim Y. Green, Robert M. Chanock, Louis Potash, Stephen D. Sears, Mary Lou Clements, Neal A. Halsey, Robert E. Black, Irene Perez-Schael

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Major advances have been made in elucidating the etiologic agents of severe infantile diarrhea, and it is clear that rotaviruses are the single most important etiologic agents. Progress in the development of rotavirus vaccine candidates has also moved swiftly with the “Jennerian” approach, in which a related live, attenuated rotaviruSi, strain from a nonhuman host is used as the immunizing antigen. If this strategy is not effective against all rotavirus serotypes, reassortant rotaviruses hold great promise for the development of a multivalent vaccine. Field trials with the “Jennerian” approach vaccines are under way, and phase 1 trials with the reassortants have been initiated.

Original language	English (US)
Pages (from-to)	S539-S546
Journal	Clinical Infectious Diseases
Volume	11
DOIs	https://doi.org/10.1093/clinids/11.Supplement_3.S539
State	Published - May 1989
Externally published	Yes

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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Kapikian, A. Z., Flores, J., Hoshino, Y., Midthun, K., Gorziglia, M., Green, K. Y., Chanock, R. M., Potash, L., Sears, S. D., Clements, M. L., Halsey, N. A., Black, R. E., & Perez-Schael, I. (1989). Prospects for development of a rotavirus vaccine against rotavirus diarrhea in infants and young children. Clinical Infectious Diseases, 11, S539-S546. https://doi.org/10.1093/clinids/11.Supplement_3.S539

Kapikian, AZ, Flores, J, Hoshino, Y, Midthun, K, Gorziglia, M, Green, KY, Chanock, RM, Potash, L, Sears, SD, Clements, ML, Halsey, NA, Black, RE & Perez-Schael, I 1989, 'Prospects for development of a rotavirus vaccine against rotavirus diarrhea in infants and young children', Clinical Infectious Diseases, vol. 11, pp. S539-S546. https://doi.org/10.1093/clinids/11.Supplement_3.S539

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abstract = "Major advances have been made in elucidating the etiologic agents of severe infantile diarrhea, and it is clear that rotaviruses are the single most important etiologic agents. Progress in the development of rotavirus vaccine candidates has also moved swiftly with the “Jennerian” approach, in which a related live, attenuated rotaviruSi, strain from a nonhuman host is used as the immunizing antigen. If this strategy is not effective against all rotavirus serotypes, reassortant rotaviruses hold great promise for the development of a multivalent vaccine. Field trials with the “Jennerian” approach vaccines are under way, and phase 1 trials with the reassortants have been initiated.",

author = "Kapikian, {Albert Z.} and Jorge Flores and Yasutaka Hoshino and Karen Midthun and Mario Gorziglia and Green, {Kim Y.} and Chanock, {Robert M.} and Louis Potash and Sears, {Stephen D.} and Clements, {Mary Lou} and Halsey, {Neal A.} and Black, {Robert E.} and Irene Perez-Schael",

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AU - Flores, Jorge

AU - Hoshino, Yasutaka

AU - Midthun, Karen

AU - Gorziglia, Mario

AU - Green, Kim Y.

AU - Chanock, Robert M.

AU - Potash, Louis

AU - Sears, Stephen D.

AU - Clements, Mary Lou

AU - Halsey, Neal A.

AU - Black, Robert E.

AU - Perez-Schael, Irene

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AB - Major advances have been made in elucidating the etiologic agents of severe infantile diarrhea, and it is clear that rotaviruses are the single most important etiologic agents. Progress in the development of rotavirus vaccine candidates has also moved swiftly with the “Jennerian” approach, in which a related live, attenuated rotaviruSi, strain from a nonhuman host is used as the immunizing antigen. If this strategy is not effective against all rotavirus serotypes, reassortant rotaviruses hold great promise for the development of a multivalent vaccine. Field trials with the “Jennerian” approach vaccines are under way, and phase 1 trials with the reassortants have been initiated.

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Prospects for development of a rotavirus vaccine against rotavirus diarrhea in infants and young children

Abstract

ASJC Scopus subject areas

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