Prospects for a novel ultrashort pulsed laser technology for pathogen inactivation

Shaw Wei D. Tsen; Tzyy Choou Wu; Juliann G. Kiang; Kong Thon Tsen

doi:10.1186/1423-0127-19-62

Prospects for a novel ultrashort pulsed laser technology for pathogen inactivation

Shaw Wei D. Tsen, Tzyy Choou Wu, Juliann G. Kiang, Kong Thon Tsen

School of Medicine

Research output: Contribution to journal › Review article › peer-review

32 Scopus citations

Abstract

The threat of emerging pathogens and microbial drug resistance has spurred tremendous efforts to develop new and more effective antimicrobial strategies. Recently, a novel ultrashort pulsed (USP) laser technology has been developed that enables efficient and chemical-free inactivation of a wide spectrum of viral and bacterial pathogens. Such a technology circumvents the need to introduce potentially toxic chemicals and could permit safe and environmentally friendly pathogen reduction, with a multitude of possible applications including the sterilization of pharmaceuticals and blood products, and the generation of attenuated or inactivated vaccines.

Original language	English (US)
Article number	62
Journal	Journal of biomedical science
Volume	19
Issue number	1
DOIs	https://doi.org/10.1186/1423-0127-19-62
State	Published - 2012

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Molecular Biology
Clinical Biochemistry
Cell Biology
Biochemistry, medical
Pharmacology (medical)

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abstract = "The threat of emerging pathogens and microbial drug resistance has spurred tremendous efforts to develop new and more effective antimicrobial strategies. Recently, a novel ultrashort pulsed (USP) laser technology has been developed that enables efficient and chemical-free inactivation of a wide spectrum of viral and bacterial pathogens. Such a technology circumvents the need to introduce potentially toxic chemicals and could permit safe and environmentally friendly pathogen reduction, with a multitude of possible applications including the sterilization of pharmaceuticals and blood products, and the generation of attenuated or inactivated vaccines.",

author = "Tsen, {Shaw Wei D.} and Wu, {Tzyy Choou} and Kiang, {Juliann G.} and Tsen, {Kong Thon}",

note = "Funding Information: The authors would like to thank Stuart M. Lindsay, Sara Vaiana, Chien-Fu Hung, Karen Kibler and Bert Jacobs for their contributions to this line of research. The research was funded by the National Science Foundation. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or reflecting the views of the Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, or the U.S. Department of Defense.",

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N1 - Funding Information: The authors would like to thank Stuart M. Lindsay, Sara Vaiana, Chien-Fu Hung, Karen Kibler and Bert Jacobs for their contributions to this line of research. The research was funded by the National Science Foundation. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or reflecting the views of the Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, or the U.S. Department of Defense.

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Prospects for a novel ultrashort pulsed laser technology for pathogen inactivation

Abstract

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