Prospects for a dengue virus vaccine

Stephen S. Whitehead, Joseph E. Blaney, Anna P. Durbin, Brian R. Murphy

Research output: Contribution to journalReview article

Abstract

The number of cases of severe dengue disease continues to grow in endemic areas of southeast Asia, Central and South America, and other subtropical regions. Children bear the greatest burden of disease, and the development of an effective vaccine remains a global public health priority. A tetravalent vaccine is urgently needed and must be effective against all four dengue virus serotypes, be cost-effective and provide long-term protection. In this Review we discuss the unique immunological concerns in dengue virus vaccine development and the current prospects for the development of an acceptable vaccine, a goal that is likely to be reached in the near future.

Original languageEnglish (US)
Pages (from-to)518-528
Number of pages11
JournalNature Reviews Microbiology
Volume5
Issue number7
DOIs
StatePublished - Jul 1 2007

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ASJC Scopus subject areas

  • Microbiology
  • Immunology and Microbiology(all)
  • Infectious Diseases

Cite this

Whitehead, S. S., Blaney, J. E., Durbin, A. P., & Murphy, B. R. (2007). Prospects for a dengue virus vaccine. Nature Reviews Microbiology, 5(7), 518-528. https://doi.org/10.1038/nrmicro1690