Prospective study of the modified atkins diet in combination with a ketogenic liquid supplement during the initial month

Eric H. Kossoff, Jennifer L. Dorward, Zahava Turner, Paula L. Pyzik

Research output: Contribution to journalArticle


The modified Atkins diet is a high-fat, low-carbohydrate treatment for intractable childhood epilepsy. As data suggest that a stricter diet onset can be more effective, we added a ketogenic supplement to the modified Atkins diet during its initial month. Thirty children with intractable epilepsy were prospectively started on the modified Atkins diet in combination with a daily 400-calorie KetoCal shake. At 1 month, 24 (80%) children had >50% seizure reduction, of which 11 (37%) had >90% seizure reduction. There was no significant loss of efficacy during the second month after KetoCal ® was discontinued. The use of this ketogenic supplement increased daily fat intake and thus the ketogenic ratio (1.8:1 versus 1.0:1 in the modified Atkins diet alone, P =.0002), but did not change urinary or serum ketosis. The addition of a ketogenic supplement to the modified Atkins diet during its initial month appears to be beneficial.

Original languageEnglish (US)
Pages (from-to)147-151
Number of pages5
JournalJournal of child neurology
Issue number2
StatePublished - Feb 1 2011



  • Atkins
  • KetoCal
  • diet
  • epilepsy
  • ketogenic
  • ketosis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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