TY - JOUR
T1 - Prospective study of the magnitude and duration of changes in tuberculin reactivity during uncomplicated and complicated measles
AU - Tamashiro, Victor G.
AU - Perez, Horestes H.
AU - Griffin, Diane E.
PY - 1987/5
Y1 - 1987/5
N2 - The suppression of cellular immune responses during measles is thought to contribute to the development of secondary infections which often complicate this disease. To determine whether there was a difference in the altered cellular immune responses of children with and without complications we performed a prospective study of purified protein derivative skin test reactivity in children with natural measles virus infections who had received Bacillus Cal-mette-Guerin as infants. Twenty-five tuberculin-positive children who developed measles (13 uncomplicated and 12 complicated) were skin-tested weekly beginning 1 to 2 weeks before and ending 2 to 7 weeks after the onset of the rash. All children became anergic during the acute phase of measles. Children with complications remained unreactive for a significantly longer period of time after the rash (mean, 4 weeks) than did children without complications (mean, 2.3 weeks, P < 0.001).
AB - The suppression of cellular immune responses during measles is thought to contribute to the development of secondary infections which often complicate this disease. To determine whether there was a difference in the altered cellular immune responses of children with and without complications we performed a prospective study of purified protein derivative skin test reactivity in children with natural measles virus infections who had received Bacillus Cal-mette-Guerin as infants. Twenty-five tuberculin-positive children who developed measles (13 uncomplicated and 12 complicated) were skin-tested weekly beginning 1 to 2 weeks before and ending 2 to 7 weeks after the onset of the rash. All children became anergic during the acute phase of measles. Children with complications remained unreactive for a significantly longer period of time after the rash (mean, 4 weeks) than did children without complications (mean, 2.3 weeks, P < 0.001).
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U2 - 10.1097/00006454-198705000-00007
DO - 10.1097/00006454-198705000-00007
M3 - Article
C2 - 3601492
AN - SCOPUS:0023258481
SN - 0891-3668
VL - 6
SP - 451
EP - 454
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
IS - 5
ER -