Prospective study of the magnitude and duration of changes in tuberculin reactivity during uncomplicated and complicated measles

Victor G. Tamashiro, Horestes H. Perez, Diane E. Griffin

Research output: Contribution to journalArticlepeer-review

Abstract

The suppression of cellular immune responses during measles is thought to contribute to the development of secondary infections which often complicate this disease. To determine whether there was a difference in the altered cellular immune responses of children with and without complications we performed a prospective study of purified protein derivative skin test reactivity in children with natural measles virus infections who had received Bacillus Cal-mette-Guerin as infants. Twenty-five tuberculin-positive children who developed measles (13 uncomplicated and 12 complicated) were skin-tested weekly beginning 1 to 2 weeks before and ending 2 to 7 weeks after the onset of the rash. All children became anergic during the acute phase of measles. Children with complications remained unreactive for a significantly longer period of time after the rash (mean, 4 weeks) than did children without complications (mean, 2.3 weeks, P < 0.001).

Original languageEnglish (US)
Pages (from-to)451-454
Number of pages4
JournalPediatric Infectious Disease Journal
Volume6
Issue number5
DOIs
StatePublished - May 1987

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

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