Prospective study of cytomegalovirus serostatus and prostate cancer risk in the Prostate Cancer Prevention Trial

Siobhan Sutcliffe, Cathee Till, Charlotte A. Gaydos, Frank J. Jenkins, Phyllis J. Goodman, Ashraful M. Hoque, Ann W. Hsing, Ian M. Thompson, Jonathan M. Zenilman, William G. Nelson, Angelo M. De Marzo, Elizabeth A. Platz

Research output: Contribution to journalArticle

Abstract

Purpose To investigate serologic evidence of infection by cytomegalovirus (CMV), a herpesvirus with known oncogenic potential that has been detected in malignant prostate tissue, in relation to prostate cancer (PCa) risk in a large case-control study nested in the Prostate Cancer Prevention Trial (PCPT). Methods Cases were men with a confirmed diagnosis of PCa after visit 2 (n = 614), and controls were men not diagnosed with PCa during the trial who also had a negative end-of-study biopsy (n = 616). Controls were frequency-matched to cases by age, treatment arm, and family history of PCa. Sera from visit 2 were tested for CMV IgG antibodies. Results No association was observed between CMV serostatus and PCa risk (adjusted CMV seroprevalence = 67.9 % for cases and 65.2 % for controls, odds ratio = 1.13, 95 % CI 0.89-1.45). Conclusions Considering our null findings in the context of the full CMV literature, CMV infection, as measured by serostatus, does not appear to increase PCa risk.

Original languageEnglish (US)
Pages (from-to)1511-1518
Number of pages8
JournalCancer Causes and Control
Volume23
Issue number9
DOIs
StatePublished - Sep 1 2012

    Fingerprint

Keywords

  • Cytomegalovirus
  • Epidemiology
  • Infection
  • Prostate cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this