Prospective randomized trial of high versus low negative pressure suction in management of chyle fistula after neck dissection for metastatic thyroid carcinoma

Gaosong Wu, Xiaofei Chang, Yun Xia, Wei Huang, Wayne M. Koch

Research output: Contribution to journalReview articlepeer-review

Abstract

Background Negative pressure drainage has been shown to be an effective treatment of chyle fistula. However, the optimal level of negative pressure has not been determined. We therefore conducted a prospective randomized trial to address this issue. Methods In all, 21 patients with chyle fistula were randomly assigned to a high negative pressure suction (HNPS) group (-600 mmHg, n = 10) or low negative pressure suction (LNPS) group (-125 mmHg, n = 11). The duration of drain leakage and hospital stay, and the incidence of complications were compared between the 2 groups. Results All patients were successfully treated with conservative management without surgical intervention. The median durations of chyle leakage and hospital stay were significantly shorter in the HNPS group compared with the LNPS group: 4 versus 7 days (p =.0048) and 5 versus 11 days (p =.0107), respectively. Conclusions Negative suction was demonstrated to be highly effective in the management of chyle fistula, and HNPS appeared to be more efficient than LNPS. © 2011 Wiley Periodicals, Inc. Head Neck, 2011

Original languageEnglish (US)
Pages (from-to)1711-1715
Number of pages5
JournalHead and Neck
Volume34
Issue number12
DOIs
StatePublished - Dec 1 2012

Keywords

  • chyle leakage
  • management
  • neck dissection
  • negative pressure
  • thyroid carcinoma

ASJC Scopus subject areas

  • Otorhinolaryngology

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