Prospective, randomized, controlled clinical trial comparing traditional versus reduced tidal volume ventilation in acute respiratory distress syndrome patients

Roy G. Brower, Carl B. Shanholtz, Henry E. Fessler, David M. Shade, Peter White, Charles M. Wiener, John G. Teeter, Jeffrey M. Dodd-o, Yaniv Almog, Steven Piantadosi

Research output: Contribution to journalArticle


Objective: To assess the safety and potential efficacy of a mechanical ventilation strategy designed to reduce stretch-induced lung injury in acute respiratory distress syndrome. Design: Prospective, randomized, controlled clinical trial. Setting: Eight intensive care units in four teaching hospitals. Patients: Fifty-two patients with acute respiratory distress syndrome. Interventions: Traditional tidal volume patients; tidal volume 10- 12 mL/kg ideal body weight, reduced if inspiratory plateau pressure was >55 cm H2O (7.3 kPa). Small tidal volume patients: tidal volume 5-8 mL/kg ideal body weight, to keep plateau pressure < 30 cm H2O (4.0 kPa). Measurements and Main Results: Mean tidal volumes during the first 5 days in traditional and small tidal volume patients were 10.2 and 7.3 mL/kg, respectively (p < .001), with mean plateau pressure = 30.6 and 24.9 cm H20 (3.3 kPa), respectively (p < .001). There were no significant differences in requirements for positive end-expiratory pressure of FIO2, fluid intakes/outputs, requirements for vasopressors, sedatives, or neuromuscular blocking agents, percentage of patients that achieved unassisted breathing, ventilator days, or mortality. Conclusions: The reduced tidal volume strategy used in this study was safe. Failure to observe beneficial effects of small tidal volume ventilation treatment in important clinical outcome variables may have occurred because a) the sample size was too small to discern small treatment effects; b) the differences in tidal volumes and plateau pressures were modest; or c) reduced tidal volume ventilation is not beneficial.

Original languageEnglish (US)
Pages (from-to)1492-1498
Number of pages7
JournalCritical care medicine
Issue number8
StatePublished - Sep 6 1999



  • Acute lung injury
  • Acute respiratory distress syndrome (ARDS)
  • Mechanical ventilation
  • Permissive hypercapnia
  • Plateau pressure
  • Tidal volume

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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