Prospective population-based incidence of Haemophilus influenzae type b meningitis in Thailand

Supachai Rerks-Ngarm; Sophie C. Treleaven; Supamit Chunsuttiwat; Charung Muangchana; Damien Jolley; Alan Brooks; Surang Dejsirilert; Sirisak Warintrawat; Malcolm Guiver; Prayura Kunasol; James E. Maynard; Beverley Ann Biggs; Mark Steinhoff

doi:10.1016/j.vaccine.2003.09.013

Prospective population-based incidence of Haemophilus influenzae type b meningitis in Thailand

Supachai Rerks-Ngarm, Sophie C. Treleaven, Supamit Chunsuttiwat, Charung Muangchana, Damien Jolley, Alan Brooks, Surang Dejsirilert, Sirisak Warintrawat, Malcolm Guiver, Prayura Kunasol, James E. Maynard, Beverley Ann Biggs, Mark Steinhoff

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

There are limited prospective data for Haemophilus influenzae type b (Hib) disease in Asia, where some countries are considering vaccine introduction. A prospective population-based study was conducted to measure the incidence of Hib meningitis in children in two northern provinces of Thailand. Children <5 years with symptoms consistent with bacterial meningitis were enrolled in the study if inclusion criteria were met. The study enrolled 598 children with clinical meningitis, 76% of whom received lumbar puncture. The rate of probable bacterial meningitis was 26.6/100,000 children <5 years per year. There were four cases of laboratory confirmed Hib meningitis (rate 3.8/100,000 children <5 years per year). These findings suggest a relatively low incidence of Hib meningitis. However, additional data from studies of pneumonia are needed to define the Hib disease burden in Thailand.

Original language	English (US)
Pages (from-to)	975-983
Number of pages	9
Journal	Vaccine
Volume	22
Issue number	8
DOIs	https://doi.org/10.1016/j.vaccine.2003.09.013
State	Published - Feb 25 2004
Externally published	Yes

Keywords

Haemophilus influenzae type b
Meningitis
Thailand

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/j.vaccine.2003.09.013

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Rerks-Ngarm, S., Treleaven, S. C., Chunsuttiwat, S., Muangchana, C., Jolley, D., Brooks, A., Dejsirilert, S., Warintrawat, S., Guiver, M., Kunasol, P., Maynard, J. E., Biggs, B. A., & Steinhoff, M. (2004). Prospective population-based incidence of Haemophilus influenzae type b meningitis in Thailand. Vaccine, 22(8), 975-983. https://doi.org/10.1016/j.vaccine.2003.09.013

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title = "Prospective population-based incidence of Haemophilus influenzae type b meningitis in Thailand",

abstract = "There are limited prospective data for Haemophilus influenzae type b (Hib) disease in Asia, where some countries are considering vaccine introduction. A prospective population-based study was conducted to measure the incidence of Hib meningitis in children in two northern provinces of Thailand. Children <5 years with symptoms consistent with bacterial meningitis were enrolled in the study if inclusion criteria were met. The study enrolled 598 children with clinical meningitis, 76% of whom received lumbar puncture. The rate of probable bacterial meningitis was 26.6/100,000 children <5 years per year. There were four cases of laboratory confirmed Hib meningitis (rate 3.8/100,000 children <5 years per year). These findings suggest a relatively low incidence of Hib meningitis. However, additional data from studies of pneumonia are needed to define the Hib disease burden in Thailand.",

keywords = "Haemophilus influenzae type b, Meningitis, Thailand",

author = "Supachai Rerks-Ngarm and Treleaven, {Sophie C.} and Supamit Chunsuttiwat and Charung Muangchana and Damien Jolley and Alan Brooks and Surang Dejsirilert and Sirisak Warintrawat and Malcolm Guiver and Prayura Kunasol and Maynard, {James E.} and Biggs, {Beverley Ann} and Mark Steinhoff",

note = "Funding Information: We acknowledge administrative assistance from MOPH and PATH staff in Bangkok, in particular Brian McLaughlin, Yuenyong Dao-Chaeng and Supadra Theplib; Hospital and Provincial Health Office staff of Lampang and Phitsanulok provinces, Virginia de Crespigny, Beth Hilton-Thorp, Karl Jenkinson, Mirella Ozols and Heather Saunders at the University of Melbourne and staff at PATH Seattle. The project was funded by the Children{\textquoteright}s Vaccine Program at PATH.",

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AU - Rerks-Ngarm, Supachai

AU - Treleaven, Sophie C.

AU - Chunsuttiwat, Supamit

AU - Muangchana, Charung

AU - Jolley, Damien

AU - Brooks, Alan

AU - Dejsirilert, Surang

AU - Warintrawat, Sirisak

AU - Guiver, Malcolm

AU - Kunasol, Prayura

AU - Maynard, James E.

AU - Biggs, Beverley Ann

AU - Steinhoff, Mark

N1 - Funding Information: We acknowledge administrative assistance from MOPH and PATH staff in Bangkok, in particular Brian McLaughlin, Yuenyong Dao-Chaeng and Supadra Theplib; Hospital and Provincial Health Office staff of Lampang and Phitsanulok provinces, Virginia de Crespigny, Beth Hilton-Thorp, Karl Jenkinson, Mirella Ozols and Heather Saunders at the University of Melbourne and staff at PATH Seattle. The project was funded by the Children’s Vaccine Program at PATH.

PY - 2004/2/25

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N2 - There are limited prospective data for Haemophilus influenzae type b (Hib) disease in Asia, where some countries are considering vaccine introduction. A prospective population-based study was conducted to measure the incidence of Hib meningitis in children in two northern provinces of Thailand. Children <5 years with symptoms consistent with bacterial meningitis were enrolled in the study if inclusion criteria were met. The study enrolled 598 children with clinical meningitis, 76% of whom received lumbar puncture. The rate of probable bacterial meningitis was 26.6/100,000 children <5 years per year. There were four cases of laboratory confirmed Hib meningitis (rate 3.8/100,000 children <5 years per year). These findings suggest a relatively low incidence of Hib meningitis. However, additional data from studies of pneumonia are needed to define the Hib disease burden in Thailand.

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Prospective population-based incidence of Haemophilus influenzae type b meningitis in Thailand

Abstract

Keywords

ASJC Scopus subject areas

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