Prospective evaluation of soft tissue masses and sarcomas using fluorodeoxyglucose positron emission tomography

J. D. Lucas, M. J. O'Doherty, B. F. Cronin, P. K. Marsden, Martin Lodge, P. H. McKeet, M. A. Smith

Research output: Contribution to journalArticle

Abstract

Background: The differentiation of soft tissue sarcoma (STS) from benign masses is difficult owing to their clinical and radiological similarities. Accurate staging is hindered by the large number of sites at which metastases may be found. This study examined the value of whole-body [18F]2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) in patients presenting with soft tissue masses. Methods: Thirty patients with a soft tissue mass suspected to be malignant were evaluated with FDG PET. The images were evaluated qualitatively and quantitatively for uptake of FDG to determine whether benign lesions could be differentiated from malignant tumours, and for the presence of metastases. Results: Thirty-one masses were removed from 30 patients; 12 were benign and 19 were malignant STSs. Using qualitative assessment of the FDG PET images, all the high-grade STSs (n = 12) were correctly identified, but low-grade STS (n = 7) could not be differentiated from a benign lesion. Using a quantification assessment, there was a 95 per cent sensitivity and a 75 per cent specificity in diagnosing STS. Three patients had metastases at presentation; two were correctly identified by FDG PET. Conclusion: FDG PET has a role in distinguishing high-grade STS from low-grade or benign STS and may have a role in staging malignant tumours.

Original languageEnglish (US)
Pages (from-to)550-556
Number of pages7
JournalBritish Journal of Surgery
Volume86
Issue number4
DOIs
StatePublished - 1999
Externally publishedYes

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Sarcoma
Positron-Emission Tomography
Deoxyglucose
Neoplasm Metastasis
Neoplasm Staging
Fluorodeoxyglucose F18
Neoplasms

ASJC Scopus subject areas

  • Surgery

Cite this

Prospective evaluation of soft tissue masses and sarcomas using fluorodeoxyglucose positron emission tomography. / Lucas, J. D.; O'Doherty, M. J.; Cronin, B. F.; Marsden, P. K.; Lodge, Martin; McKeet, P. H.; Smith, M. A.

In: British Journal of Surgery, Vol. 86, No. 4, 1999, p. 550-556.

Research output: Contribution to journalArticle

Lucas, J. D. ; O'Doherty, M. J. ; Cronin, B. F. ; Marsden, P. K. ; Lodge, Martin ; McKeet, P. H. ; Smith, M. A. / Prospective evaluation of soft tissue masses and sarcomas using fluorodeoxyglucose positron emission tomography. In: British Journal of Surgery. 1999 ; Vol. 86, No. 4. pp. 550-556.
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abstract = "Background: The differentiation of soft tissue sarcoma (STS) from benign masses is difficult owing to their clinical and radiological similarities. Accurate staging is hindered by the large number of sites at which metastases may be found. This study examined the value of whole-body [18F]2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) in patients presenting with soft tissue masses. Methods: Thirty patients with a soft tissue mass suspected to be malignant were evaluated with FDG PET. The images were evaluated qualitatively and quantitatively for uptake of FDG to determine whether benign lesions could be differentiated from malignant tumours, and for the presence of metastases. Results: Thirty-one masses were removed from 30 patients; 12 were benign and 19 were malignant STSs. Using qualitative assessment of the FDG PET images, all the high-grade STSs (n = 12) were correctly identified, but low-grade STS (n = 7) could not be differentiated from a benign lesion. Using a quantification assessment, there was a 95 per cent sensitivity and a 75 per cent specificity in diagnosing STS. Three patients had metastases at presentation; two were correctly identified by FDG PET. Conclusion: FDG PET has a role in distinguishing high-grade STS from low-grade or benign STS and may have a role in staging malignant tumours.",
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AU - O'Doherty, M. J.

AU - Cronin, B. F.

AU - Marsden, P. K.

AU - Lodge, Martin

AU - McKeet, P. H.

AU - Smith, M. A.

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