Prospective evaluation of PSMA-targeted 18F-DCFPYL PET/CT in men with biochemical failure after radical prostatectomy for prostate cancer

Steven P. Rowe, Scott P. Campbell, Margarita Mana-Ay, Zsolt Szabo, Mohamad E. Allaf, Kenneth J. Pienta, Martin G. Pomper, Ashley E. Ross, Michael A. Gorin

Research output: Contribution to journalArticle

Abstract

Our purpose is to provide the results of a prospective study evaluating prostate-specific membrane antigen–targeted 18F-DCFPyL (2-(3-{1-carboxy-5-[(6-18F-fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)pentanedioic acid) PET/CT in patients with biochemical failure after radical prostatectomy for prostate cancer (PCa). Methods: Thirty-one patients with postprostatectomy serum prostate-specific antigen (PSA) levels of at least 0.2 ng/mL and negative conventional imaging results were enrolled in this study and imaged with 18F-DCFPyL PET/CT. A consensus central review identified foci of radiotracer uptake consistent with sites of PCa. Descriptive statistics were used. Results: Twenty-one patients (67.7%) had at least 1 finding on 18F-DCFPyL PET/CT consistent with a site of PCa. Imaging was positive in 59.1% of patients with a PSA level of less than 1.0 ng/mL and in 88.9% of patients with a PSA level of more than 1.0 ng/mL. The median SUVmax across all lesions was 11.6 (range, 1.5–57.6). Conclusion: In this prospective study using the prostate-specific membrane antigen–targeted PET agent 18F-DCFPyL, most patients with biochemical failure after radical prostatectomy had foci of suggestive uptake, even at low serum PSA levels.

Original languageEnglish (US)
Pages (from-to)58-61
Number of pages4
JournalJournal of Nuclear Medicine
Volume61
Issue number1
DOIs
StatePublished - Jan 2020

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Keywords

  • Biochemical persistence
  • Biochemical recurrence
  • Genitourinary
  • Oncology
  • PET/CT
  • Prostate-specific membrane antigen

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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