Prospective comparative study of the influence of postoperative bile reflux on gastric mucosal histology and Campylobacter pylori infection

G. J A Offerhaus, P. N M A Rieu, J. B M J Jansen, H. J M Joosten, C. B H W Lamers

Research output: Contribution to journalArticlepeer-review

Abstract

Biopsies of 17 peptic ulcer patients, randomly treated by partial gastrectomy with either Billroth-II (n = 9) or Roux-en-Y (n = 8) anastomosis were studied before and six months after surgery to determine the role of bile reflux in the early postoperative histological alterations of the gastric mucosa. After BII-gastrectomy bile acid reflux (median 16.1 μmol/h) was significantly higher (p <0.0001) than after RY-gastrectomy (0.1 μmol/h). Campylobacter pylori was present in the preoperative biopsies of all 17 patients. After RY-gastrectomy biopsies of all eight patients were positive for Campylobacter pylori, but was detected in only five of the nine patients with BII-gastrectomy. Properative scores of gastritis grading were similar in both groups and no significant differences were found postoperatively. Gastritis scores of the anastomotic mucosa in patients with BII-gastrectomy were significantly higher (p

Original languageEnglish (US)
Pages (from-to)1552-1557
Number of pages6
JournalGut
Volume30
Issue number11
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology

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