Prospective cohort study of mother-to-infant infection and clearance of hepatitis C in rural Egyptian villages

Fatma M. Shebl, Samer S. El-Kamary, Doa'a A. Saleh, Mohamed Abdel-Hamid, Nabiel Mikhail, Alif Allam, Hanaa El-Arabi, Ibrahim Elhenawy, Sherif El-Kafrawy, Mai El-Daly, Sahar Selim, Ayman Abd El-Wahab, Mohamed Mostafa, Soraya Sharaf, Mohamed Hashem, Scott Heyward, O. Colin Stine, Laurence S. Magder, Sonia Stoszek, G. Thomas Strickland

Research output: Contribution to journalArticle

Abstract

Although persistent transmission of hepatitis C virus (HCV) from infected mothers to their infants is reported in 4-8%, transient HCV perinatal infection also occurs. This prospective cohort study determined perinatal HCV infection- and early and late clearance-rates in 1,863 mother-infant pairs in rural Egyptian villages. This study found 15.7% and 10.9% of pregnant women had HCV antibodies (anti-HCV) and HCV-RNA, respectively. Among 329 infants born of these mothers, 33 (10.0%) tested positive for both anti-HCV and HCV-RNA 2 months following birth-29 (12.5%) having HCV-RNA positive mothers and 4 (with transient infections) having mothers with only anti-HCV. Fifteen remained HCV-RNA positive at one and/or 2 years (persistent infections), while 18 cleared both virus and antibody by 1 year (transient infections). Among the 15 persistent cases, 7 cleared their infections by 2 or 3 years. At 2- to 6- and at 10- to 12-month maternally acquired anti-HCV was observed in 80% and 5% of infants, respectively. Four perinatally infected and one transiently infected infant were confirmed to be infected by their mothers by the sequence similarity of their viruses. Viremia was 155-fold greater in mothers of infants with persistent than mothers of infants with transient infections. Maternal-infant transmission of HCV is more frequent than generally reported. However, both early and late clearance of infection frequently occurs and only 15 (4.6%) and 8 (2.4%) infants born of HCV-RNA positive mothers had detectable HCV-RNA at one and 2-3 years of age. Investigating how infants clear infection may provide important information about protective immunity to HCV.

Original languageEnglish (US)
Pages (from-to)1024-1031
Number of pages8
JournalJournal of Medical Virology
Volume81
Issue number6
DOIs
StatePublished - Jun 2009
Externally publishedYes

Fingerprint

Hepatitis C
Hepacivirus
Cohort Studies
Mothers
Prospective Studies
Infection
RNA
Hepatitis C Antibodies
Virus Diseases
Viruses
Viremia
Pregnant Women
Immunity

Keywords

  • Hepatitis C virus
  • Perinatal transmission
  • Risk factors
  • Transient infection
  • Viral clearance

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Shebl, F. M., El-Kamary, S. S., Saleh, D. A., Abdel-Hamid, M., Mikhail, N., Allam, A., ... Strickland, G. T. (2009). Prospective cohort study of mother-to-infant infection and clearance of hepatitis C in rural Egyptian villages. Journal of Medical Virology, 81(6), 1024-1031. https://doi.org/10.1002/jmv.21480

Prospective cohort study of mother-to-infant infection and clearance of hepatitis C in rural Egyptian villages. / Shebl, Fatma M.; El-Kamary, Samer S.; Saleh, Doa'a A.; Abdel-Hamid, Mohamed; Mikhail, Nabiel; Allam, Alif; El-Arabi, Hanaa; Elhenawy, Ibrahim; El-Kafrawy, Sherif; El-Daly, Mai; Selim, Sahar; El-Wahab, Ayman Abd; Mostafa, Mohamed; Sharaf, Soraya; Hashem, Mohamed; Heyward, Scott; Stine, O. Colin; Magder, Laurence S.; Stoszek, Sonia; Strickland, G. Thomas.

In: Journal of Medical Virology, Vol. 81, No. 6, 06.2009, p. 1024-1031.

Research output: Contribution to journalArticle

Shebl, FM, El-Kamary, SS, Saleh, DA, Abdel-Hamid, M, Mikhail, N, Allam, A, El-Arabi, H, Elhenawy, I, El-Kafrawy, S, El-Daly, M, Selim, S, El-Wahab, AA, Mostafa, M, Sharaf, S, Hashem, M, Heyward, S, Stine, OC, Magder, LS, Stoszek, S & Strickland, GT 2009, 'Prospective cohort study of mother-to-infant infection and clearance of hepatitis C in rural Egyptian villages', Journal of Medical Virology, vol. 81, no. 6, pp. 1024-1031. https://doi.org/10.1002/jmv.21480
Shebl, Fatma M. ; El-Kamary, Samer S. ; Saleh, Doa'a A. ; Abdel-Hamid, Mohamed ; Mikhail, Nabiel ; Allam, Alif ; El-Arabi, Hanaa ; Elhenawy, Ibrahim ; El-Kafrawy, Sherif ; El-Daly, Mai ; Selim, Sahar ; El-Wahab, Ayman Abd ; Mostafa, Mohamed ; Sharaf, Soraya ; Hashem, Mohamed ; Heyward, Scott ; Stine, O. Colin ; Magder, Laurence S. ; Stoszek, Sonia ; Strickland, G. Thomas. / Prospective cohort study of mother-to-infant infection and clearance of hepatitis C in rural Egyptian villages. In: Journal of Medical Virology. 2009 ; Vol. 81, No. 6. pp. 1024-1031.
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