Pros and cons of vaginal brachytherapy after external beam radiation therapy in endometrial cancer

Devarati Mitra, Ann H. Klopp, Akila Viswanathan

Research output: Contribution to journalArticle

Abstract

A large number of studies have looked at the role of radiation therapy in the treatment of endometrial cancer. One particular radiation strategy in common practice is the use of adjuvant external beam (EB) radiotherapy followed by vaginal brachytherapy (VB). While the addition of VB to EB provides a theoretical benefit of a localized boost with higher focused dose to an area of potentially high recurrence risk, a randomized clinical trial to compare outcomes and toxicities of EB + VB vs. EB alone is lacking. The goal of this review is to present the current data for and against the use of this combined radiation modality and to provide some preliminary evidence regarding which patient populations may be most likely to benefit.

Original languageEnglish (US)
Pages (from-to)167-175
Number of pages9
JournalGynecologic Oncology
Volume140
Issue number1
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

Fingerprint

Brachytherapy
Endometrial Neoplasms
Radiotherapy
Radiation
Randomized Controlled Trials
Recurrence
Population
Therapeutics

Keywords

  • Endometrial cancer
  • External beam radiation therapy
  • Vaginal brachytherapy

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology
  • Medicine(all)

Cite this

Pros and cons of vaginal brachytherapy after external beam radiation therapy in endometrial cancer. / Mitra, Devarati; Klopp, Ann H.; Viswanathan, Akila.

In: Gynecologic Oncology, Vol. 140, No. 1, 01.01.2016, p. 167-175.

Research output: Contribution to journalArticle

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