Propofol effects on cerebellar long-term depression

Kwan Young Lee, Young Im Kim, Se Hoon Kim, Hyung Seo Park, Youn Joon Park, Myung Sook Ha, Yunju Jin, Dong Kwan Kim

Research output: Contribution to journalArticle

Abstract

Propofol is an intravenously administered anesthetic that induces γ-aminobutyric acid-mediated inhibition in the central nervous system. It has been implicated in prolonged movement disorders. Since the cerebellum is important for motor coordination and learning, we investigated the potential effects of propofol on cerebellar circuitry. Using the whole-cell patch-clamp technique in Wister rat cerebellar slices, we demonstrated that propofol administration impaired long-term depression from the parallel fiber (PF) to Purkinje cell (PC) synapses (PF-LTD). Also, propofol reduced metabotropic glutamate receptor 1 (mGluR1)-mediated and group I mGluR agonist-induced slow currents in PCs. These results suggest that the propofol-induced PF-LTD impairment may be related to an alteration in mGluR1 signaling, which is essential to motor learning.

Original languageEnglish (US)
Pages (from-to)18-22
Number of pages5
JournalNeuroscience Letters
Volume609
DOIs
StatePublished - Nov 16 2015

Keywords

  • Cerebellum
  • Long-term depression
  • Metabotropic glutamate receptor 1
  • Parallel fiber
  • Propofol
  • Purkinje cell

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Lee, K. Y., Kim, Y. I., Kim, S. H., Park, H. S., Park, Y. J., Ha, M. S., Jin, Y., & Kim, D. K. (2015). Propofol effects on cerebellar long-term depression. Neuroscience Letters, 609, 18-22. https://doi.org/10.1016/j.neulet.2015.09.037