Propofol effects on cerebellar long-term depression

Kwan Young Lee; Young Im Kim; Se Hoon Kim; Hyung Seo Park; Youn Joon Park; Myung Sook Ha; Yunju Jin; Dong Kwan Kim

doi:10.1016/j.neulet.2015.09.037

Propofol effects on cerebellar long-term depression

Kwan Young Lee, Young Im Kim, Se Hoon Kim, Hyung Seo Park, Youn Joon Park, Myung Sook Ha, Yunju Jin, Dong Kwan Kim

School of Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Propofol is an intravenously administered anesthetic that induces γ-aminobutyric acid-mediated inhibition in the central nervous system. It has been implicated in prolonged movement disorders. Since the cerebellum is important for motor coordination and learning, we investigated the potential effects of propofol on cerebellar circuitry. Using the whole-cell patch-clamp technique in Wister rat cerebellar slices, we demonstrated that propofol administration impaired long-term depression from the parallel fiber (PF) to Purkinje cell (PC) synapses (PF-LTD). Also, propofol reduced metabotropic glutamate receptor 1 (mGluR1)-mediated and group I mGluR agonist-induced slow currents in PCs. These results suggest that the propofol-induced PF-LTD impairment may be related to an alteration in mGluR1 signaling, which is essential to motor learning.

Original language	English (US)
Pages (from-to)	18-22
Number of pages	5
Journal	Neuroscience Letters
Volume	609
DOIs	https://doi.org/10.1016/j.neulet.2015.09.037
State	Published - Nov 16 2015

Keywords

Cerebellum
Long-term depression
Metabotropic glutamate receptor 1
Parallel fiber
Propofol
Purkinje cell

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neulet.2015.09.037

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title = "Propofol effects on cerebellar long-term depression",

abstract = "Propofol is an intravenously administered anesthetic that induces γ-aminobutyric acid-mediated inhibition in the central nervous system. It has been implicated in prolonged movement disorders. Since the cerebellum is important for motor coordination and learning, we investigated the potential effects of propofol on cerebellar circuitry. Using the whole-cell patch-clamp technique in Wister rat cerebellar slices, we demonstrated that propofol administration impaired long-term depression from the parallel fiber (PF) to Purkinje cell (PC) synapses (PF-LTD). Also, propofol reduced metabotropic glutamate receptor 1 (mGluR1)-mediated and group I mGluR agonist-induced slow currents in PCs. These results suggest that the propofol-induced PF-LTD impairment may be related to an alteration in mGluR1 signaling, which is essential to motor learning.",

keywords = "Cerebellum, Long-term depression, Metabotropic glutamate receptor 1, Parallel fiber, Propofol, Purkinje cell",

author = "Lee, {Kwan Young} and Kim, {Young Im} and Kim, {Se Hoon} and Park, {Hyung Seo} and Park, {Youn Joon} and Ha, {Myung Sook} and Yunju Jin and Kim, {Dong Kwan}",

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year = "2015",

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doi = "10.1016/j.neulet.2015.09.037",

language = "English (US)",

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T1 - Propofol effects on cerebellar long-term depression

AU - Lee, Kwan Young

AU - Kim, Young Im

AU - Kim, Se Hoon

AU - Park, Hyung Seo

AU - Park, Youn Joon

AU - Ha, Myung Sook

AU - Jin, Yunju

AU - Kim, Dong Kwan

PY - 2015/11/16

Y1 - 2015/11/16

N2 - Propofol is an intravenously administered anesthetic that induces γ-aminobutyric acid-mediated inhibition in the central nervous system. It has been implicated in prolonged movement disorders. Since the cerebellum is important for motor coordination and learning, we investigated the potential effects of propofol on cerebellar circuitry. Using the whole-cell patch-clamp technique in Wister rat cerebellar slices, we demonstrated that propofol administration impaired long-term depression from the parallel fiber (PF) to Purkinje cell (PC) synapses (PF-LTD). Also, propofol reduced metabotropic glutamate receptor 1 (mGluR1)-mediated and group I mGluR agonist-induced slow currents in PCs. These results suggest that the propofol-induced PF-LTD impairment may be related to an alteration in mGluR1 signaling, which is essential to motor learning.

AB - Propofol is an intravenously administered anesthetic that induces γ-aminobutyric acid-mediated inhibition in the central nervous system. It has been implicated in prolonged movement disorders. Since the cerebellum is important for motor coordination and learning, we investigated the potential effects of propofol on cerebellar circuitry. Using the whole-cell patch-clamp technique in Wister rat cerebellar slices, we demonstrated that propofol administration impaired long-term depression from the parallel fiber (PF) to Purkinje cell (PC) synapses (PF-LTD). Also, propofol reduced metabotropic glutamate receptor 1 (mGluR1)-mediated and group I mGluR agonist-induced slow currents in PCs. These results suggest that the propofol-induced PF-LTD impairment may be related to an alteration in mGluR1 signaling, which is essential to motor learning.

KW - Cerebellum

KW - Long-term depression

KW - Metabotropic glutamate receptor 1

KW - Parallel fiber

KW - Propofol

KW - Purkinje cell

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SN - 0304-3940

VL - 609

SP - 18

EP - 22

JO - Neuroscience Letters

JF - Neuroscience Letters

ER -

Propofol effects on cerebellar long-term depression

Abstract

Keywords

ASJC Scopus subject areas

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