Prophylactic Vaccines for Nonviral Cancers

Research output: Contribution to journalReview articlepeer-review

Abstract

The successful development of prophylactic cancer vaccines targeting oncogenic viruses has demonstrated the potential for vaccination to reduce the global burden of cancer. However, most human cancers are not caused by viruses, and therefore novel approaches are needed for the successful development of prophylactic cancer vaccines for nonviral cancers. In this review, we detail evidence that the human immune system can recognize and eliminate non-virus-caused cancers before they become clinically apparent. We also discuss the design of an ideal prophylactic vaccine with the goal of providing a lasting adaptive immune response against antigen targets that arise early in a cancer's development.

Original languageEnglish (US)
Pages (from-to)193-211
Number of pages19
JournalAnnual Review of Cancer Biology
Volume2
DOIs
StatePublished - 2018

Keywords

  • cancer
  • immunity
  • nonviral
  • oncoantigen
  • prevention
  • vaccine

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Oncology

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