TY - JOUR
T1 - Prophylactic effect of magnesium infusion against postoperative atrial fibrillation
AU - Naito, Yuji
AU - Nakajima, Masato
AU - Inoue, Hidenori
AU - Hibino, Narutoshi
AU - Mizutani, Eiki
AU - Tsuchiya, Koji
PY - 2006/8
Y1 - 2006/8
N2 - BACKGROUND: Atrial fibrillation (AF) is a common complication of cardiac operation. For the development of postoperative AF, various risk factors have been identified over the years. In a recent study, it was detected that low serum magnesium levels was an independent predictor of AF after coronary artery bypass grafting (CABG). The purpose of this study was to assess the prophylactic effect of intravenous magnesium infusion on postoperative AF. METHODS: A total of 62 consecutive patients who had elective, first time cardiac operation on cardiopulmonary bypass were prospectively categorized to 2 group. In the treatment group, 30 patients received 8.3 mmol of magnesium sulfate in 100 ml of saline solution that was administered over 4 hours, preoperatively, just after admission in the ICU, and at the postoperative day 1, 2, 3, and 4. RESULTS: Postoperative AF occurred in 3/30 (10.0%) patients in the treatment group and in 14/32 (43.8%) patients in the control group (p<0.01). The arrhythmia developed on the 2.9 postoperative day on average. The postoperative length of hospital stay was significantly shortened in the treatment group (15.9 +/- 4.0 days) than that in the control group (20.5 +/- 7.0, p < 0.01). CONCLUSION: Our findings indicate that magnesium sulfate infusion is effective for the prophylaxis of post operative AF.
AB - BACKGROUND: Atrial fibrillation (AF) is a common complication of cardiac operation. For the development of postoperative AF, various risk factors have been identified over the years. In a recent study, it was detected that low serum magnesium levels was an independent predictor of AF after coronary artery bypass grafting (CABG). The purpose of this study was to assess the prophylactic effect of intravenous magnesium infusion on postoperative AF. METHODS: A total of 62 consecutive patients who had elective, first time cardiac operation on cardiopulmonary bypass were prospectively categorized to 2 group. In the treatment group, 30 patients received 8.3 mmol of magnesium sulfate in 100 ml of saline solution that was administered over 4 hours, preoperatively, just after admission in the ICU, and at the postoperative day 1, 2, 3, and 4. RESULTS: Postoperative AF occurred in 3/30 (10.0%) patients in the treatment group and in 14/32 (43.8%) patients in the control group (p<0.01). The arrhythmia developed on the 2.9 postoperative day on average. The postoperative length of hospital stay was significantly shortened in the treatment group (15.9 +/- 4.0 days) than that in the control group (20.5 +/- 7.0, p < 0.01). CONCLUSION: Our findings indicate that magnesium sulfate infusion is effective for the prophylaxis of post operative AF.
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M3 - Article
C2 - 16922436
AN - SCOPUS:33749167712
SN - 0021-5252
VL - 59
JO - Kyobu geka. The Japanese journal of thoracic surgery.
JF - Kyobu geka. The Japanese journal of thoracic surgery.
IS - 9
ER -