Prophylactic doxycycline for travelers' diarrhea. Results of a prospective double-blind study of Peace Corps Volunteers in Morocco

R. Bradley Sack; Jean L. Froehlich; Alan W. Zulich; Dolores Sidi Hidi; Albert Z. Kapikian; Frits Ørskov; Ida Ørskov; Harry B. Greenberg

doi:10.1016/0016-5085(79)90403-7

Prophylactic doxycycline for travelers' diarrhea. Results of a prospective double-blind study of Peace Corps Volunteers in Morocco

R. Bradley Sack, Jean L. Froehlich, Alan W. Zulich, Dolores Sidi Hidi, Albert Z. Kapikian, Frits Ørskov, Ida Ørskov, Harry B. Greenberg

School of Medicine

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

A second randomized double-blind study to determine the efficacy of doxycycline, 100 mg daily, for the prevention of travelers' diarrhea was carried out among 50 Peace Corps Volunteers during their first 10 wk in Morocco. The volunteers took either doxycycline or placebo for 3 wk, and were observed for an additional 7 wk. Eleven of 24 taking the placebo and 2 of 26 taking doxycycline had travelers' diarrhea during the treatment period (P < 0.01). One week after cessation of the doxycycline, however, persons in that group developed an increase in frequency of travelers' diarrhea (P < 0.05) so that by 3 wk after the drug was stopped, there were no differences between the groups. Enterotoxigenic E. coli, most of which were sensitive to doxycycline, were the most frequently isolated pathogens during the entire study. This study corroborates the effectiveness of doxycycline prophylaxis for travelers' diarrhea.

Original language	English (US)
Pages (from-to)	1368-1373
Number of pages	6
Journal	Gastroenterology
Volume	76
Issue number	6
DOIs	https://doi.org/10.1016/0016-5085(79)90403-7
State	Published - Jun 1979

ASJC Scopus subject areas

Hepatology
Gastroenterology

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title = "Prophylactic doxycycline for travelers' diarrhea. Results of a prospective double-blind study of Peace Corps Volunteers in Morocco",

abstract = "A second randomized double-blind study to determine the efficacy of doxycycline, 100 mg daily, for the prevention of travelers' diarrhea was carried out among 50 Peace Corps Volunteers during their first 10 wk in Morocco. The volunteers took either doxycycline or placebo for 3 wk, and were observed for an additional 7 wk. Eleven of 24 taking the placebo and 2 of 26 taking doxycycline had travelers' diarrhea during the treatment period (P < 0.01). One week after cessation of the doxycycline, however, persons in that group developed an increase in frequency of travelers' diarrhea (P < 0.05) so that by 3 wk after the drug was stopped, there were no differences between the groups. Enterotoxigenic E. coli, most of which were sensitive to doxycycline, were the most frequently isolated pathogens during the entire study. This study corroborates the effectiveness of doxycycline prophylaxis for travelers' diarrhea.",

author = "Sack, {R. Bradley} and Froehlich, {Jean L.} and Zulich, {Alan W.} and Hidi, {Dolores Sidi} and Kapikian, {Albert Z.} and Frits {\O}rskov and Ida {\O}rskov and Greenberg, {Harry B.}",

year = "1979",

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AU - Sack, R. Bradley

AU - Froehlich, Jean L.

AU - Zulich, Alan W.

AU - Hidi, Dolores Sidi

AU - Kapikian, Albert Z.

AU - Ørskov, Frits

AU - Ørskov, Ida

AU - Greenberg, Harry B.

PY - 1979/6

Y1 - 1979/6

N2 - A second randomized double-blind study to determine the efficacy of doxycycline, 100 mg daily, for the prevention of travelers' diarrhea was carried out among 50 Peace Corps Volunteers during their first 10 wk in Morocco. The volunteers took either doxycycline or placebo for 3 wk, and were observed for an additional 7 wk. Eleven of 24 taking the placebo and 2 of 26 taking doxycycline had travelers' diarrhea during the treatment period (P < 0.01). One week after cessation of the doxycycline, however, persons in that group developed an increase in frequency of travelers' diarrhea (P < 0.05) so that by 3 wk after the drug was stopped, there were no differences between the groups. Enterotoxigenic E. coli, most of which were sensitive to doxycycline, were the most frequently isolated pathogens during the entire study. This study corroborates the effectiveness of doxycycline prophylaxis for travelers' diarrhea.

AB - A second randomized double-blind study to determine the efficacy of doxycycline, 100 mg daily, for the prevention of travelers' diarrhea was carried out among 50 Peace Corps Volunteers during their first 10 wk in Morocco. The volunteers took either doxycycline or placebo for 3 wk, and were observed for an additional 7 wk. Eleven of 24 taking the placebo and 2 of 26 taking doxycycline had travelers' diarrhea during the treatment period (P < 0.01). One week after cessation of the doxycycline, however, persons in that group developed an increase in frequency of travelers' diarrhea (P < 0.05) so that by 3 wk after the drug was stopped, there were no differences between the groups. Enterotoxigenic E. coli, most of which were sensitive to doxycycline, were the most frequently isolated pathogens during the entire study. This study corroborates the effectiveness of doxycycline prophylaxis for travelers' diarrhea.

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Prophylactic doxycycline for travelers' diarrhea. Results of a prospective double-blind study of Peace Corps Volunteers in Morocco

Abstract

ASJC Scopus subject areas

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