Prophylactic doxycycline for travelers' diarrhea in Thailand: Further supportive evidence of aeromonas hydrophila as an enteric pathogen

Peter Echeverria, R. Bradley Sack, Neil R. Blacklow, Premthavi Bodhidatta, Bernard Rowe, Albert Mcfarland

Research output: Contribution to journalArticlepeer-review

Abstract

A randomized double-blind study to determine the efficacy of a three-week course of doxycycline (100 mg daily) in preventing travelers' diarrhea was performed in 1980 among 63 United States Peace Corps volunteers during their first five weeks in Thailand, an area where doxycycline-resistant enterotoxigenic Escherichia coli are known to be common. Eight (24%) of 33 volunteers taking placebo and 3 (10%) of 30 taking doxycycilne developed travelers' diarrhea for a calculated protection of 59%, but this was not statistically significant (p = 0.12). Aeromonas hydrophila was isolated from 8 of 19 volunteers with either travelers' diarrhea or mild diarrhea in the placebo group, but from only 1 of 12 in the doxycycilne group (p ≤ 0.05). Furthermore, doxycycline significantly prevented colonization of the gastrointestinal tract with A. hydrophila while it was being taken (p≤0.01). Enterotoxlgenic E. coil was isolated from only one volunteer with travelers' diarrhea in the placebo group and from none in the doxycycilne group. Doxycycilne prophylaxis of travelers' diarrhea in this geographic area, though not shown to be significantly protective, further sup ports the role of A. hydrophila as an enteric pathogen.

Original languageEnglish (US)
Pages (from-to)912-921
Number of pages10
JournalAmerican journal of epidemiology
Volume120
Issue number6
DOIs
StatePublished - Dec 1984

Keywords

  • Aeromonas
  • Diarrhea
  • Doxycycline
  • Enterotoxins
  • Escherichia coli

ASJC Scopus subject areas

  • Epidemiology

Fingerprint Dive into the research topics of 'Prophylactic doxycycline for travelers' diarrhea in Thailand: Further supportive evidence of aeromonas hydrophila as an enteric pathogen'. Together they form a unique fingerprint.

Cite this