Prophylactic antibiotics adversely affect nosocomial pneumonia in trauma patients

J. Jason Hoth, Glen A. Franklin, Nicole A. Stassen, Stephen M. Girard, Roman J. Rodriguez, Jorge L. Rodriguez, Addison K. May, Martin A. Croce, Grant V. Bochicchio, Collin E M Brathwaite

Research output: Contribution to journalArticle

Abstract

Background: Little data are available regarding the impact that prolonged prophylactic antibiotic use (>48 hours) has on the development of nosocomial pneumonia. This retrospective study was conducted to assess the effect that prolonged prophylactic antibiotic use has on the development of nosocomial pneumonia and antibiotic use complications. Methods: The records of patients who contracted nosocomial pneumonia during mechanical ventilation were retrospectively reviewed. These patients then were classified into two groups: those who received prolonged prophylactic antibiotics before the diagnosis of pneumonia and those who did not receive antibiotics. Results: For the patients who received prolonged prophylactic antibiotics, the first pneumonia was diagnosed later, the causative organisms were more likely to be resistant or Gram-negative bacteria, and the incidence of antibiotic complications were two times greater than for patients who did not receive extended antibiotic prophylaxis. Conclusion: Justification for the use and duration of prolonged (>48 hours) prophylactic antibiotics requires careful reevaluation because this practice is associated with significant clinical complications that lead to increased use of patient resources, lengthened hospital stay, and higher cost.

Original languageEnglish (US)
Pages (from-to)249-254
Number of pages6
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume55
Issue number2
DOIs
StatePublished - Aug 1 2003
Externally publishedYes

Keywords

  • Nosocomial pneumonia
  • Prophylactic antibiotics
  • Trauma

ASJC Scopus subject areas

  • Surgery

Fingerprint Dive into the research topics of 'Prophylactic antibiotics adversely affect nosocomial pneumonia in trauma patients'. Together they form a unique fingerprint.

  • Cite this

    Hoth, J. J., Franklin, G. A., Stassen, N. A., Girard, S. M., Rodriguez, R. J., Rodriguez, J. L., May, A. K., Croce, M. A., Bochicchio, G. V., & Brathwaite, C. E. M. (2003). Prophylactic antibiotics adversely affect nosocomial pneumonia in trauma patients. Journal of Trauma - Injury, Infection and Critical Care, 55(2), 249-254. https://doi.org/10.1097/01.TA.0000083334.93868.65