Propagation wavefronts in two-dimensional topologies of cardiac cell networks

Matthew G. Fishler, Nitish V Thakor, Philip Reidt

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We present a computer model, implemented on a Cray-2 supercomputer, to explore the role of the discontinuous, nonuniform, and anisotropic cellular structure of cardiac tissue on normal propagation patterns. For this study, we hold cell shape constant and evaluate planar propagation wavefronts oriented longitudinally and transversely to the cell axis for two different tissue topologies-rectangular and brick-like-and for different degrees of transverse coupling strengths between cells. Nonuniformity is introduced into the model via spatial dispersions of coupling strengths. Even under severe conditions of uncoupling, both topologies show remarkable abilities in maintaining a uniformly planar wavefront. Thus, our simulations suggest that cardiac cell networks are very robust in their abilities to equilibrate electrical spatial inhomogeneities, even in the face of significant structural and coupling inhomogeneities.

Original languageEnglish (US)
Title of host publicationProceedings - Computers in Cardiology, CIC 1992
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages411-414
Number of pages4
ISBN (Electronic)0818635525, 9780818635526
DOIs
StatePublished - Jan 1 1992
Event1992 IEEE Conference on Computers in Cardiology, CIC 1992 - Durham, United States
Duration: Oct 11 1992Oct 14 1992

Publication series

NameProceedings - Computers in Cardiology, CIC 1992

Conference

Conference1992 IEEE Conference on Computers in Cardiology, CIC 1992
CountryUnited States
CityDurham
Period10/11/9210/14/92

Fingerprint

Wavefronts
Topology
Tissue
Supercomputers
Brick
Dispersions
Cell Shape
Cellular Structures
Computer Simulation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Health Informatics
  • Computer Science Applications
  • Biomedical Engineering

Cite this

Fishler, M. G., Thakor, N. V., & Reidt, P. (1992). Propagation wavefronts in two-dimensional topologies of cardiac cell networks. In Proceedings - Computers in Cardiology, CIC 1992 (pp. 411-414). [269501] (Proceedings - Computers in Cardiology, CIC 1992). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/CIC.1992.269501

Propagation wavefronts in two-dimensional topologies of cardiac cell networks. / Fishler, Matthew G.; Thakor, Nitish V; Reidt, Philip.

Proceedings - Computers in Cardiology, CIC 1992. Institute of Electrical and Electronics Engineers Inc., 1992. p. 411-414 269501 (Proceedings - Computers in Cardiology, CIC 1992).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Fishler, MG, Thakor, NV & Reidt, P 1992, Propagation wavefronts in two-dimensional topologies of cardiac cell networks. in Proceedings - Computers in Cardiology, CIC 1992., 269501, Proceedings - Computers in Cardiology, CIC 1992, Institute of Electrical and Electronics Engineers Inc., pp. 411-414, 1992 IEEE Conference on Computers in Cardiology, CIC 1992, Durham, United States, 10/11/92. https://doi.org/10.1109/CIC.1992.269501
Fishler MG, Thakor NV, Reidt P. Propagation wavefronts in two-dimensional topologies of cardiac cell networks. In Proceedings - Computers in Cardiology, CIC 1992. Institute of Electrical and Electronics Engineers Inc. 1992. p. 411-414. 269501. (Proceedings - Computers in Cardiology, CIC 1992). https://doi.org/10.1109/CIC.1992.269501
Fishler, Matthew G. ; Thakor, Nitish V ; Reidt, Philip. / Propagation wavefronts in two-dimensional topologies of cardiac cell networks. Proceedings - Computers in Cardiology, CIC 1992. Institute of Electrical and Electronics Engineers Inc., 1992. pp. 411-414 (Proceedings - Computers in Cardiology, CIC 1992).
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