Prompting asthma intervention in rochester-uniting parents and providers (PAIR-UP): A randomized trial

Jill S. Halterman, Maria Fagnano, Paul J. Tremblay, Susan G. Fisher, Hongyue Wang, Cynthia Rand, Peter Szilagyi, Arlene Butz

Research output: Contribution to journalArticlepeer-review


IMPORTANCE: A disproportionate number of impoverished and minority children have asthma and receive suboptimal preventive care.

OBJECTIVE: To evaluate whether the Prompting Asthma Intervention in Rochester-Uniting Parents and Providers (PAIR-UP) intervention, administered in primary care offices, improves the delivery of preventive care and reduces morbidity for urban children with asthma.

DESIGN, SETTING, AND PARTICIPANTS: Cluster randomized trial in which 12 urban primary care practices were matched based on size and type and randomly allocated to the PAIR-UP intervention or usual care (UC).We enrolled 638 children aged 2 to 12 years with persistent or poorly controlled asthma in the waiting room prior to a visit with a clinician for any reason from October 2009 to January 2013. Blinded interviewers called caregivers within 2 weeks to inquire about preventive measures taken at the visit and called them 2 and 6 months later to assess symptoms.

INTERVENTIONS: Children enrolled at PAIR-UP practices received prompts for the caregiver and clinician at the time of the visit that outlined the child's asthma severity or control as well as specific guideline-based recommendations to enhance preventive care. These practices also received educational resources and periodic feedback on their asthma care performance. The UC practices received copies of the asthma guidelines.

MAIN OUTCOMES AND MEASURES: The primary outcomewas symptom-free days (SFDs) per 2 weeks at the 2-month follow-up.

RESULTS: We enrolled 638 children (participation rate of 80%; 36%were black, 36%were Hispanic, and 68%had Medicaid insurance). Groups were similar in demographic characteristics and asthma severity at baseline. At the index visit, more children in the PAIR-UP group received a preventive medication action (new medication, increased dose, recommendation to restart preventive medication) than in the UC group (58%vs 33%; odds ratio [OR] = 2.8; 95%CI, 1.9 to 3.9). More children in the PAIR-UP group than in the UC group received an asthma action plan (61% vs 23%; OR = 8.3; 95%CI, 3.7 to 18.7), discussions regarding asthma (93%vs 78%; OR = 4.5; 95%CI, 2.8 to 7.2), and secondhand smoke counseling (80% vs 63%; OR = 2.6; 95%CI, 1.2 to 5.5). At the 2-month follow-up, children in the PAIR-UP group had more SFDs per 2 weeks than those in the UC group (mean difference, 0.78 days; 95%CI, 0.29 to 1.27). At 6 months, the improvement in SFDs was no longer statistically significant (mean difference, 0.56; 95%CI, -0.14 to 1.25).

CONCLUSIONS AND RELEVANCE: The PAIR-UP intervention improved the delivery of preventive asthma care and reduced asthma morbidity for high-risk urban children with persistent asthma at 2 months, but the improvement in SFDs was no longer significant at 6 months.

Original languageEnglish (US)
Pages (from-to)e141983
JournalJAMA pediatrics
Issue number10
StatePublished - Oct 1 2014

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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