Promotion of cholera awareness among households of cholera patients: A randomized controlled trial of the cholera-hospital-based-intervention-for-7 days (chobi7) intervention

K. M. Saif-Ur-Rahman, Tahmina Parvin, Sazzadul Islam Bhuyian, Fatema Zohura, Farzana Begum, Mahamud Ur Rashid, Shwapon Kumar Biswas, David Sack, R. Bradley Sack, Shirajum Monira, Munirul Alam, Nusrat Jahan Shaly, Christine Marie George

Research output: Contribution to journalArticlepeer-review

Abstract

Previous studies have demonstrated that household contacts of cholera patients are highly susceptible to cholera infections for a 7-day period after the presentation of the index patient in the hospital. However, there is no standard of care to prevent cholera transmission in this high-risk population. Furthermore, there is limited information available on awareness of cholera transmission and prevention among cholera patients and their household contacts. To initiate a standard of care for this high-risk population, we developed the Cholera-Hospital-Based-Intervention-for-7-Days (CHoBI7), which delivers a handwashing with soap and water treatment intervention to household contacts during the time they spend with the admitted cholera patient in the hospital and reinforces these messages through home visits. To test CHoBI7, we conducted a randomized controlled trial among 302 intervention cholera patient household members and 302 control cholera patient household members in Dhaka, Bangladesh. In this study, we evaluated the effectiveness of the CHoBI7 intervention in increasing awareness of cholera transmission and prevention, and the key times for handwashing with soap. We observed a significant increase in cholera knowledge score in the intervention arm compared with the control arm at both the 1-week follow-up {score coefficient = 2.34 (95% confidence interval [CI] = 1.96, 2.71)} and 6 to 12-month follow-up period (score coefficient = 1.59 [95% CI = 1.05, 2.13]). This 1-week hospital-and home-based intervention led to a significant increase in knowledge of cholera transmission and prevention which was sustained 6 to 12 months post-intervention. These findings suggest that the CHoBI7 intervention presents a promising approach to increase cholera awareness among this high-risk population.

Original languageEnglish (US)
Pages (from-to)1292-1298
Number of pages7
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume95
Issue number6
DOIs
StatePublished - Dec 2016

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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