Promotion of cholera awareness among households of cholera patients: A randomized controlled trial of the cholera-hospital-based-intervention-for-7 days (chobi7) intervention

K. M. Saif-Ur-Rahman, Tahmina Parvin, Sazzadul Islam Bhuyian, Fatema Zohura, Farzana Begum, Mahamud Ur Rashid, Shwapon Kumar Biswas, David Allen Sack, R. Bradley Sack, Shirajum Monira, Munirul Alam, Nusrat Jahan Shaly, Christine Marie George

Research output: Contribution to journalArticle

Abstract

Previous studies have demonstrated that household contacts of cholera patients are highly susceptible to cholera infections for a 7-day period after the presentation of the index patient in the hospital. However, there is no standard of care to prevent cholera transmission in this high-risk population. Furthermore, there is limited information available on awareness of cholera transmission and prevention among cholera patients and their household contacts. To initiate a standard of care for this high-risk population, we developed the Cholera-Hospital-Based-Intervention-for-7-Days (CHoBI7), which delivers a handwashing with soap and water treatment intervention to household contacts during the time they spend with the admitted cholera patient in the hospital and reinforces these messages through home visits. To test CHoBI7, we conducted a randomized controlled trial among 302 intervention cholera patient household members and 302 control cholera patient household members in Dhaka, Bangladesh. In this study, we evaluated the effectiveness of the CHoBI7 intervention in increasing awareness of cholera transmission and prevention, and the key times for handwashing with soap. We observed a significant increase in cholera knowledge score in the intervention arm compared with the control arm at both the 1-week follow-up {score coefficient = 2.34 (95% confidence interval [CI] = 1.96, 2.71)} and 6 to 12-month follow-up period (score coefficient = 1.59 [95% CI = 1.05, 2.13]). This 1-week hospital-and home-based intervention led to a significant increase in knowledge of cholera transmission and prevention which was sustained 6 to 12 months post-intervention. These findings suggest that the CHoBI7 intervention presents a promising approach to increase cholera awareness among this high-risk population.

Original languageEnglish (US)
Pages (from-to)1292-1298
Number of pages7
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume95
Issue number6
DOIs
StatePublished - Dec 1 2016

Fingerprint

Cholera
Randomized Controlled Trials
Hand Disinfection
Soaps
Standard of Care
Confidence Intervals
Population
House Calls
Bangladesh
Water Purification

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Virology

Cite this

Promotion of cholera awareness among households of cholera patients : A randomized controlled trial of the cholera-hospital-based-intervention-for-7 days (chobi7) intervention. / Saif-Ur-Rahman, K. M.; Parvin, Tahmina; Bhuyian, Sazzadul Islam; Zohura, Fatema; Begum, Farzana; Rashid, Mahamud Ur; Biswas, Shwapon Kumar; Sack, David Allen; Sack, R. Bradley; Monira, Shirajum; Alam, Munirul; Shaly, Nusrat Jahan; George, Christine Marie.

In: American Journal of Tropical Medicine and Hygiene, Vol. 95, No. 6, 01.12.2016, p. 1292-1298.

Research output: Contribution to journalArticle

Saif-Ur-Rahman, K. M. ; Parvin, Tahmina ; Bhuyian, Sazzadul Islam ; Zohura, Fatema ; Begum, Farzana ; Rashid, Mahamud Ur ; Biswas, Shwapon Kumar ; Sack, David Allen ; Sack, R. Bradley ; Monira, Shirajum ; Alam, Munirul ; Shaly, Nusrat Jahan ; George, Christine Marie. / Promotion of cholera awareness among households of cholera patients : A randomized controlled trial of the cholera-hospital-based-intervention-for-7 days (chobi7) intervention. In: American Journal of Tropical Medicine and Hygiene. 2016 ; Vol. 95, No. 6. pp. 1292-1298.
@article{e1424f4effcc4d72acc8c828422687e1,
title = "Promotion of cholera awareness among households of cholera patients: A randomized controlled trial of the cholera-hospital-based-intervention-for-7 days (chobi7) intervention",
abstract = "Previous studies have demonstrated that household contacts of cholera patients are highly susceptible to cholera infections for a 7-day period after the presentation of the index patient in the hospital. However, there is no standard of care to prevent cholera transmission in this high-risk population. Furthermore, there is limited information available on awareness of cholera transmission and prevention among cholera patients and their household contacts. To initiate a standard of care for this high-risk population, we developed the Cholera-Hospital-Based-Intervention-for-7-Days (CHoBI7), which delivers a handwashing with soap and water treatment intervention to household contacts during the time they spend with the admitted cholera patient in the hospital and reinforces these messages through home visits. To test CHoBI7, we conducted a randomized controlled trial among 302 intervention cholera patient household members and 302 control cholera patient household members in Dhaka, Bangladesh. In this study, we evaluated the effectiveness of the CHoBI7 intervention in increasing awareness of cholera transmission and prevention, and the key times for handwashing with soap. We observed a significant increase in cholera knowledge score in the intervention arm compared with the control arm at both the 1-week follow-up {score coefficient = 2.34 (95{\%} confidence interval [CI] = 1.96, 2.71)} and 6 to 12-month follow-up period (score coefficient = 1.59 [95{\%} CI = 1.05, 2.13]). This 1-week hospital-and home-based intervention led to a significant increase in knowledge of cholera transmission and prevention which was sustained 6 to 12 months post-intervention. These findings suggest that the CHoBI7 intervention presents a promising approach to increase cholera awareness among this high-risk population.",
author = "Saif-Ur-Rahman, {K. M.} and Tahmina Parvin and Bhuyian, {Sazzadul Islam} and Fatema Zohura and Farzana Begum and Rashid, {Mahamud Ur} and Biswas, {Shwapon Kumar} and Sack, {David Allen} and Sack, {R. Bradley} and Shirajum Monira and Munirul Alam and Shaly, {Nusrat Jahan} and George, {Christine Marie}",
year = "2016",
month = "12",
day = "1",
doi = "10.4269/ajtmh.16-0378",
language = "English (US)",
volume = "95",
pages = "1292--1298",
journal = "American Journal of Tropical Medicine and Hygiene",
issn = "0002-9637",
publisher = "American Society of Tropical Medicine and Hygiene",
number = "6",

}

TY - JOUR

T1 - Promotion of cholera awareness among households of cholera patients

T2 - A randomized controlled trial of the cholera-hospital-based-intervention-for-7 days (chobi7) intervention

AU - Saif-Ur-Rahman, K. M.

AU - Parvin, Tahmina

AU - Bhuyian, Sazzadul Islam

AU - Zohura, Fatema

AU - Begum, Farzana

AU - Rashid, Mahamud Ur

AU - Biswas, Shwapon Kumar

AU - Sack, David Allen

AU - Sack, R. Bradley

AU - Monira, Shirajum

AU - Alam, Munirul

AU - Shaly, Nusrat Jahan

AU - George, Christine Marie

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Previous studies have demonstrated that household contacts of cholera patients are highly susceptible to cholera infections for a 7-day period after the presentation of the index patient in the hospital. However, there is no standard of care to prevent cholera transmission in this high-risk population. Furthermore, there is limited information available on awareness of cholera transmission and prevention among cholera patients and their household contacts. To initiate a standard of care for this high-risk population, we developed the Cholera-Hospital-Based-Intervention-for-7-Days (CHoBI7), which delivers a handwashing with soap and water treatment intervention to household contacts during the time they spend with the admitted cholera patient in the hospital and reinforces these messages through home visits. To test CHoBI7, we conducted a randomized controlled trial among 302 intervention cholera patient household members and 302 control cholera patient household members in Dhaka, Bangladesh. In this study, we evaluated the effectiveness of the CHoBI7 intervention in increasing awareness of cholera transmission and prevention, and the key times for handwashing with soap. We observed a significant increase in cholera knowledge score in the intervention arm compared with the control arm at both the 1-week follow-up {score coefficient = 2.34 (95% confidence interval [CI] = 1.96, 2.71)} and 6 to 12-month follow-up period (score coefficient = 1.59 [95% CI = 1.05, 2.13]). This 1-week hospital-and home-based intervention led to a significant increase in knowledge of cholera transmission and prevention which was sustained 6 to 12 months post-intervention. These findings suggest that the CHoBI7 intervention presents a promising approach to increase cholera awareness among this high-risk population.

AB - Previous studies have demonstrated that household contacts of cholera patients are highly susceptible to cholera infections for a 7-day period after the presentation of the index patient in the hospital. However, there is no standard of care to prevent cholera transmission in this high-risk population. Furthermore, there is limited information available on awareness of cholera transmission and prevention among cholera patients and their household contacts. To initiate a standard of care for this high-risk population, we developed the Cholera-Hospital-Based-Intervention-for-7-Days (CHoBI7), which delivers a handwashing with soap and water treatment intervention to household contacts during the time they spend with the admitted cholera patient in the hospital and reinforces these messages through home visits. To test CHoBI7, we conducted a randomized controlled trial among 302 intervention cholera patient household members and 302 control cholera patient household members in Dhaka, Bangladesh. In this study, we evaluated the effectiveness of the CHoBI7 intervention in increasing awareness of cholera transmission and prevention, and the key times for handwashing with soap. We observed a significant increase in cholera knowledge score in the intervention arm compared with the control arm at both the 1-week follow-up {score coefficient = 2.34 (95% confidence interval [CI] = 1.96, 2.71)} and 6 to 12-month follow-up period (score coefficient = 1.59 [95% CI = 1.05, 2.13]). This 1-week hospital-and home-based intervention led to a significant increase in knowledge of cholera transmission and prevention which was sustained 6 to 12 months post-intervention. These findings suggest that the CHoBI7 intervention presents a promising approach to increase cholera awareness among this high-risk population.

UR - http://www.scopus.com/inward/record.url?scp=85005976199&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85005976199&partnerID=8YFLogxK

U2 - 10.4269/ajtmh.16-0378

DO - 10.4269/ajtmh.16-0378

M3 - Article

C2 - 27799644

AN - SCOPUS:85005976199

VL - 95

SP - 1292

EP - 1298

JO - American Journal of Tropical Medicine and Hygiene

JF - American Journal of Tropical Medicine and Hygiene

SN - 0002-9637

IS - 6

ER -