Promoter-associated RNAs and promoter-targeted RNAs

Bing Xue Yan, Jin Xia Ma

Research output: Contribution to journalReview articlepeer-review

Abstract

The world of RNAs is much more complex than previously thought, and has rapidly emerged as one of the most actively researched topics in the life sciences. Recently, two findings in this field were reported and given special attention: promoter-associated RNAs (paRNAs), a novel class of RNAs with numerous potential functions; and promoter-targeted RNA-induced transcriptional gene regulation, a new regulatory mechanism to control transcription. In this review, we summarize the studies in these two areas, and outline the current understanding with respect to the potential biological functions of paRNAs, and the molecular mechanisms of promoter-targeted RNA-induced transcriptional gene silencing and activation. Additionally, we seek to integrate these two areas, as paRNAs may have potential biological links with promoter-targeted RNA-induced transcriptional gene regulation. Finally, we will discuss the significance of identifying paRNAs and the possible use of promoter-targeted RNAs in gene regulation and therapy.

Original languageEnglish (US)
Pages (from-to)2833-2842
Number of pages10
JournalCellular and Molecular Life Sciences
Volume69
Issue number17
DOIs
StatePublished - Sep 1 2012

Keywords

  • Activation
  • Promoter
  • RNA
  • Silencing
  • Transcription

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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