Prom1 function in development, intestinal inflammation, and intestinal tumorigenesis

Baktiar O. Karim, Ki Jong Rhee, Guosheng Liu, Kyuson Yun, Steven R. Brant

Research output: Contribution to journalArticle

Abstract

Prom1/CD133 has been identified in colorectal, hepatocellular, and pancreatic cancer as a cancer stem cell marker and has been used as such to predict colon cancer recurrence in humans. Its potential molecular function as well as its role as a marker of intestinal regeneration is still not fully known. We evaluated the role of Prom1 in intestinal regeneration in inflammatory bowel disease (IBD), determined the function of Prom1, and characterized the effect of a lack of Prom1 on intestinal tumor formation in animal models. Our results suggest that Apc mutations lead to an increase in Prom1 expressing cells in the intestinal crypt stem cell compartment and in early intestinal adenomas. Also, Prom1 knockout mice are more susceptible to intestinal tumor formation. We conclude that Prom1 likely plays a role in regulating intestinal homeostasis and that these results clearly illustrate the role of Prom1 in intestinal regeneration. We further conclude that Prom1 may provide a novel therapeutic target for patients with gastrointestinal conditions such as IBD, short bowel syndrome, and colorectal cancer.

Original languageEnglish (US)
Article numberArticle 323
JournalFrontiers in Oncology
Volume4
Issue numberNOV
DOIs
StatePublished - 2014

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Regeneration
Carcinogenesis
Inflammation
Inflammatory Bowel Diseases
Colorectal Neoplasms
Short Bowel Syndrome
Neoplastic Stem Cells
Liver Neoplasms
Pancreatic Neoplasms
Knockout Mice
Adenoma
Colonic Neoplasms
Neoplasms
Homeostasis
Stem Cells
Animal Models
Recurrence
Mutation
Therapeutics

Keywords

  • Apc Min mice
  • CD133
  • Colitis-associated colon cancer
  • IBD
  • Prominin1

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Prom1 function in development, intestinal inflammation, and intestinal tumorigenesis. / Karim, Baktiar O.; Rhee, Ki Jong; Liu, Guosheng; Yun, Kyuson; Brant, Steven R.

In: Frontiers in Oncology, Vol. 4, No. NOV, Article 323, 2014.

Research output: Contribution to journalArticle

Karim, Baktiar O. ; Rhee, Ki Jong ; Liu, Guosheng ; Yun, Kyuson ; Brant, Steven R. / Prom1 function in development, intestinal inflammation, and intestinal tumorigenesis. In: Frontiers in Oncology. 2014 ; Vol. 4, No. NOV.
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