Prolonged waiting times for liver transplantation in obese patients

Dorry Segev, Richard Thompson, Jayme E. Locke, Christopher E. Simpkins, Paul J. Thuluvath, Robert A. Montgomery, Warren R. Maley

Research output: Contribution to journalArticle

Abstract

Objective: To quantify the independent association between obesity and access to liver transplantation. Background: Obesity is associated with higher complication rates, longer hospitalization, and worse survival after liver transplantation. Nevertheless, transplantation provides survival benefit to patients with end-stage liver disease, regardless of body mass index (BMI). We hypothesized that, despite survival benefit, providers were reluctant to transplant obese patients because of the inherent difficulty of these cases and their inferior outcomes. Our goal was to quantify the independent association between BMI and waiting time for orthotopic liver transplantation as a surrogate marker for this reluctance. Methods: We studied 29,136 wait-list candidates in the model for end-stage liver disease (MELD) era, categorized as severely obese (BMI 35-40), morbidly obese (BMI 40-60), and reference (BMI 18.5-35). All models were adjusted for factors relevant to the allocation system, factors possibly influencing access to healthcare, and factors biologically related to disease progression and outcomes. Results: The odds of receiving a MELD exception were 30% lower in severely obese and 38% lower in morbidly obese patients. Similarly, the likelihoods of being turned down for an organ were 10% and 16% higher, and the rates of being transplanted were 11% and 29% lower in severely obese and morbidly obese patients, respectively. Conclusions: Current practice seems to indicate a reluctance to transplant obese patients. If indeed as a community we feel that liver allografts should not be distributed to patients with excessive postoperative risk, we should consider expressing this as a formal change to our allocation policy rather than through informal practice patterns.

Original languageEnglish (US)
Pages (from-to)863-870
Number of pages8
JournalAnnals of Surgery
Volume248
Issue number5
DOIs
StatePublished - Nov 2008

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Liver Transplantation
Body Mass Index
End Stage Liver Disease
Survival
Obesity
Transplants
Allografts
Disease Progression
Hospitalization
Transplantation
Biomarkers
Delivery of Health Care
Liver

ASJC Scopus subject areas

  • Surgery

Cite this

Segev, D., Thompson, R., Locke, J. E., Simpkins, C. E., Thuluvath, P. J., Montgomery, R. A., & Maley, W. R. (2008). Prolonged waiting times for liver transplantation in obese patients. Annals of Surgery, 248(5), 863-870. https://doi.org/10.1097/SLA.0b013e31818a01ef

Prolonged waiting times for liver transplantation in obese patients. / Segev, Dorry; Thompson, Richard; Locke, Jayme E.; Simpkins, Christopher E.; Thuluvath, Paul J.; Montgomery, Robert A.; Maley, Warren R.

In: Annals of Surgery, Vol. 248, No. 5, 11.2008, p. 863-870.

Research output: Contribution to journalArticle

Segev, D, Thompson, R, Locke, JE, Simpkins, CE, Thuluvath, PJ, Montgomery, RA & Maley, WR 2008, 'Prolonged waiting times for liver transplantation in obese patients', Annals of Surgery, vol. 248, no. 5, pp. 863-870. https://doi.org/10.1097/SLA.0b013e31818a01ef
Segev, Dorry ; Thompson, Richard ; Locke, Jayme E. ; Simpkins, Christopher E. ; Thuluvath, Paul J. ; Montgomery, Robert A. ; Maley, Warren R. / Prolonged waiting times for liver transplantation in obese patients. In: Annals of Surgery. 2008 ; Vol. 248, No. 5. pp. 863-870.
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