Prolonged Elevation of Transaminase Concentration in Children With Unsuspected Myopathy

Kathleen B. Schwarz; Garrett C. Burris; Daphne E. Demello; Jeffrey S. Hyams; Jeffrey A. Biller; Martin G. Maksimak; Harland S. Winter; Richard J. Grand

doi:10.1001/archpedi.1984.02140500027009

Prolonged Elevation of Transaminase Concentration in Children With Unsuspected Myopathy

Kathleen B. Schwarz, Garrett C. Burris, Daphne E. Demello, Jeffrey S. Hyams, Jeffrey A. Biller, Martin G. Maksimak, Harland S. Winter, Richard J. Grand

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Prolonged elevation of the serum transaminase concentration in an asymptomatic child is usually thought to be secondary to liver disease. Four children with unexplained persistent elevation of serum transaminase concentration were referred to a pediatric gastroenterologist for studies of liver disease. Subsequent evaluation disclosed abnormal muscle biopsy findings in all four patients. This experience suggests that an appropriate workup for occult myopathy is indicated in such patients before invasive diagnostic procedures for evaluation of liver disease are undertaken.

Original language	English (US)
Pages (from-to)	1121-1124
Number of pages	4
Journal	American Journal of Diseases of Children
Volume	138
Issue number	12
DOIs	https://doi.org/10.1001/archpedi.1984.02140500027009
State	Published - Dec 1984
Externally published	Yes

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1001/archpedi.1984.02140500027009

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title = "Prolonged Elevation of Transaminase Concentration in Children With Unsuspected Myopathy",

abstract = "Prolonged elevation of the serum transaminase concentration in an asymptomatic child is usually thought to be secondary to liver disease. Four children with unexplained persistent elevation of serum transaminase concentration were referred to a pediatric gastroenterologist for studies of liver disease. Subsequent evaluation disclosed abnormal muscle biopsy findings in all four patients. This experience suggests that an appropriate workup for occult myopathy is indicated in such patients before invasive diagnostic procedures for evaluation of liver disease are undertaken.",

author = "Schwarz, {Kathleen B.} and Burris, {Garrett C.} and Demello, {Daphne E.} and Hyams, {Jeffrey S.} and Biller, {Jeffrey A.} and Maksimak, {Martin G.} and Winter, {Harland S.} and Grand, {Richard J.}",

note = "Funding Information: MichaelBrooke,MD,participatedinmanaging patient 1 and John Partin, MD, reviewed the electronmicrographsoftheliverincase1. This investigation wassupportedinpartby PediatrieGastroenterologyResearchTraining grant AM-07333 from the National Institute of Arthritis,Diabetes,andDigestiveandKidney Disease(DrMaksimak)andClinicalGastroen¬ terologyFellowshipfromtheCysticFibrosis Foundation(Dr Biller).",

year = "1984",

month = dec,

doi = "10.1001/archpedi.1984.02140500027009",

language = "English (US)",

volume = "138",

pages = "1121--1124",

journal = "American Journal of Diseases of Children",

issn = "0002-922X",

publisher = "American Medical Association",

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T1 - Prolonged Elevation of Transaminase Concentration in Children With Unsuspected Myopathy

AU - Schwarz, Kathleen B.

AU - Burris, Garrett C.

AU - Demello, Daphne E.

AU - Hyams, Jeffrey S.

AU - Biller, Jeffrey A.

AU - Maksimak, Martin G.

AU - Winter, Harland S.

AU - Grand, Richard J.

N1 - Funding Information: MichaelBrooke,MD,participatedinmanaging patient 1 and John Partin, MD, reviewed the electronmicrographsoftheliverincase1. This investigation wassupportedinpartby PediatrieGastroenterologyResearchTraining grant AM-07333 from the National Institute of Arthritis,Diabetes,andDigestiveandKidney Disease(DrMaksimak)andClinicalGastroen¬ terologyFellowshipfromtheCysticFibrosis Foundation(Dr Biller).

PY - 1984/12

Y1 - 1984/12

N2 - Prolonged elevation of the serum transaminase concentration in an asymptomatic child is usually thought to be secondary to liver disease. Four children with unexplained persistent elevation of serum transaminase concentration were referred to a pediatric gastroenterologist for studies of liver disease. Subsequent evaluation disclosed abnormal muscle biopsy findings in all four patients. This experience suggests that an appropriate workup for occult myopathy is indicated in such patients before invasive diagnostic procedures for evaluation of liver disease are undertaken.

AB - Prolonged elevation of the serum transaminase concentration in an asymptomatic child is usually thought to be secondary to liver disease. Four children with unexplained persistent elevation of serum transaminase concentration were referred to a pediatric gastroenterologist for studies of liver disease. Subsequent evaluation disclosed abnormal muscle biopsy findings in all four patients. This experience suggests that an appropriate workup for occult myopathy is indicated in such patients before invasive diagnostic procedures for evaluation of liver disease are undertaken.

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Prolonged Elevation of Transaminase Concentration in Children With Unsuspected Myopathy

Abstract

ASJC Scopus subject areas

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