TY - JOUR
T1 - Prolonged disynaptic inhibition in the cortex mediated by slow, non-α7 nicotinic excitation of a specific subset of cortical interneurons
AU - Arroyo, Sergio
AU - Bennett, Corbett
AU - Aziz, David
AU - Brown, Solange P.
AU - Hestrin, Shaul
PY - 2012/3/14
Y1 - 2012/3/14
N2 - Cholinergic activation of nicotinic receptors in the cortex plays a critical role in arousal, attention, and learning. Herewedemonstrate that cholinergic axons from the basal forebrain of mice excite a specific subset of cortical interneurons via a remarkably slow, non-α7 nicotinic receptor-mediated conductance. In turn, these inhibitory cells generate a delayed and prolonged wave of disynaptic inhibition in neighboring cortical neurons, altering the spatiotemporal pattern of inhibition in cortical circuits.
AB - Cholinergic activation of nicotinic receptors in the cortex plays a critical role in arousal, attention, and learning. Herewedemonstrate that cholinergic axons from the basal forebrain of mice excite a specific subset of cortical interneurons via a remarkably slow, non-α7 nicotinic receptor-mediated conductance. In turn, these inhibitory cells generate a delayed and prolonged wave of disynaptic inhibition in neighboring cortical neurons, altering the spatiotemporal pattern of inhibition in cortical circuits.
UR - http://www.scopus.com/inward/record.url?scp=84858016917&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84858016917&partnerID=8YFLogxK
U2 - 10.1523/JNEUROSCI.0115-12.2012
DO - 10.1523/JNEUROSCI.0115-12.2012
M3 - Article
C2 - 22423106
AN - SCOPUS:84858016917
SN - 0270-6474
VL - 32
SP - 3859
EP - 3864
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 11
ER -