Prolonged disynaptic inhibition in the cortex mediated by slow, non-α7 nicotinic excitation of a specific subset of cortical interneurons

Sergio Arroyo, Corbett Bennett, David Aziz, Solange P. Brown, Shaul Hestrin

Research output: Contribution to journalArticlepeer-review

Abstract

Cholinergic activation of nicotinic receptors in the cortex plays a critical role in arousal, attention, and learning. Herewedemonstrate that cholinergic axons from the basal forebrain of mice excite a specific subset of cortical interneurons via a remarkably slow, non-α7 nicotinic receptor-mediated conductance. In turn, these inhibitory cells generate a delayed and prolonged wave of disynaptic inhibition in neighboring cortical neurons, altering the spatiotemporal pattern of inhibition in cortical circuits.

Original languageEnglish (US)
Pages (from-to)3859-3864
Number of pages6
JournalJournal of Neuroscience
Volume32
Issue number11
DOIs
StatePublished - Mar 14 2012

ASJC Scopus subject areas

  • Neuroscience(all)

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