Prolongation of the cardiac QTc interval in Turner syndrome

Carolyn A. Bondy, Phillip Van, Vladimir K. Bakalov, Vandana Sachdev, Carol A. Malone, Vincent B. Ho, Douglas R. Rosing

Research output: Contribution to journalArticle

Abstract

Anatomic anomalies of the cardiovascular system occur in ∼50% of individuals with Turner syndrome (TS), with the specific genetic cause(s) for the heart defects still unknown. Because congenital heart disease may be associated with conduction system abnormalities, we compared electrocardiograms (ECGs) in 100 women with TS and 100 age-matched female controls. Women with TS were significantly more likely to demonstrate left posterior fascicular block (p < 0.005), accelerated AV conduction (p < 0.006), and T wave abnormalities (p < 0.006). The PR interval was significantly shorter (137 ± 17 vs. 158 ± 18 ms, p < 0.0001) and the rate-corrected QT interval (QTc) significantly longer in women with TS than in controls (423 ± 19 ms vs. 397 ± 18 ms; p < 0.0001). Twenty-one women with TS but no controls had a QTc greater than 440 ms. We found no statistically significant relation between body habitus, cardiac dimensions, evidence of congenital heart disease, or metabolic parameters and the incidence of ECG abnormalities or QTc duration in TS. Cardiac conduction and repolarization abnormalities appear to be intrinsic features of TS, suggesting that deletion of the second sex chromosome has more profound effects on the cardiovascular system than previously recognized, and that ECG analysis should be included in evaluating and monitoring patients with Turner syndrome.

Original languageEnglish (US)
Pages (from-to)75-81
Number of pages7
JournalMedicine
Volume85
Issue number2
DOIs
StatePublished - Mar 1 2006
Externally publishedYes

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Turner Syndrome
Electrocardiography
Cardiovascular System
Heart Diseases
Sex Chromosomes
Bundle-Branch Block
Physiologic Monitoring
Incidence

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bondy, C. A., Van, P., Bakalov, V. K., Sachdev, V., Malone, C. A., Ho, V. B., & Rosing, D. R. (2006). Prolongation of the cardiac QTc interval in Turner syndrome. Medicine, 85(2), 75-81. https://doi.org/10.1097/01.md.0000205629.16302.bc

Prolongation of the cardiac QTc interval in Turner syndrome. / Bondy, Carolyn A.; Van, Phillip; Bakalov, Vladimir K.; Sachdev, Vandana; Malone, Carol A.; Ho, Vincent B.; Rosing, Douglas R.

In: Medicine, Vol. 85, No. 2, 01.03.2006, p. 75-81.

Research output: Contribution to journalArticle

Bondy, CA, Van, P, Bakalov, VK, Sachdev, V, Malone, CA, Ho, VB & Rosing, DR 2006, 'Prolongation of the cardiac QTc interval in Turner syndrome', Medicine, vol. 85, no. 2, pp. 75-81. https://doi.org/10.1097/01.md.0000205629.16302.bc
Bondy CA, Van P, Bakalov VK, Sachdev V, Malone CA, Ho VB et al. Prolongation of the cardiac QTc interval in Turner syndrome. Medicine. 2006 Mar 1;85(2):75-81. https://doi.org/10.1097/01.md.0000205629.16302.bc
Bondy, Carolyn A. ; Van, Phillip ; Bakalov, Vladimir K. ; Sachdev, Vandana ; Malone, Carol A. ; Ho, Vincent B. ; Rosing, Douglas R. / Prolongation of the cardiac QTc interval in Turner syndrome. In: Medicine. 2006 ; Vol. 85, No. 2. pp. 75-81.
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