Prolongation of refractoriness by trains of subthreshold high-frequency stimuli

A simulation study

J. Saiz, J. M. Ferrero, J. Chorro, M. Monserrat, V. Torres, J. M. Ferrero, Nitish V Thakor

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The effect of subthreshold high-frequency stimuli (TSc) on the prolongation of the refractory period (ERP) was studied using a computer model of a segment of ventricular tissue. The electrical behavior of each cell has been simulated using the Luo and Rudy phase II model. Trains of subthreshold high-frequency stimuli, at different frequencies, were applied between two suprathreshold pulses S1 and S2. Our results show that when the TSc frequencies increases the ERP is elevated. The results also suggest that the delaying of recovery from inactivation of the fast INa current may be partially responsible for the ERP prolongation.

Original languageEnglish (US)
Title of host publicationComputers in Cardiology
PublisherIEEE Comp Soc
Pages709-712
Number of pages4
StatePublished - 1997
Externally publishedYes
EventProceedings of the 1997 24th Annual Meeting on Computers in Cardiology - Lund, Sweden
Duration: Sep 7 1997Sep 10 1997

Other

OtherProceedings of the 1997 24th Annual Meeting on Computers in Cardiology
CityLund, Sweden
Period9/7/979/10/97

Fingerprint

Enterprise resource planning
Computer Simulation
Refractory materials
Cells
Tissue
Recovery

ASJC Scopus subject areas

  • Software
  • Cardiology and Cardiovascular Medicine

Cite this

Saiz, J., Ferrero, J. M., Chorro, J., Monserrat, M., Torres, V., Ferrero, J. M., & Thakor, N. V. (1997). Prolongation of refractoriness by trains of subthreshold high-frequency stimuli: A simulation study. In Computers in Cardiology (pp. 709-712). IEEE Comp Soc.

Prolongation of refractoriness by trains of subthreshold high-frequency stimuli : A simulation study. / Saiz, J.; Ferrero, J. M.; Chorro, J.; Monserrat, M.; Torres, V.; Ferrero, J. M.; Thakor, Nitish V.

Computers in Cardiology. IEEE Comp Soc, 1997. p. 709-712.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Saiz, J, Ferrero, JM, Chorro, J, Monserrat, M, Torres, V, Ferrero, JM & Thakor, NV 1997, Prolongation of refractoriness by trains of subthreshold high-frequency stimuli: A simulation study. in Computers in Cardiology. IEEE Comp Soc, pp. 709-712, Proceedings of the 1997 24th Annual Meeting on Computers in Cardiology, Lund, Sweden, 9/7/97.
Saiz J, Ferrero JM, Chorro J, Monserrat M, Torres V, Ferrero JM et al. Prolongation of refractoriness by trains of subthreshold high-frequency stimuli: A simulation study. In Computers in Cardiology. IEEE Comp Soc. 1997. p. 709-712
Saiz, J. ; Ferrero, J. M. ; Chorro, J. ; Monserrat, M. ; Torres, V. ; Ferrero, J. M. ; Thakor, Nitish V. / Prolongation of refractoriness by trains of subthreshold high-frequency stimuli : A simulation study. Computers in Cardiology. IEEE Comp Soc, 1997. pp. 709-712
@inproceedings{8e7afd5309e1486f8301ee8812823cb0,
title = "Prolongation of refractoriness by trains of subthreshold high-frequency stimuli: A simulation study",
abstract = "The effect of subthreshold high-frequency stimuli (TSc) on the prolongation of the refractory period (ERP) was studied using a computer model of a segment of ventricular tissue. The electrical behavior of each cell has been simulated using the Luo and Rudy phase II model. Trains of subthreshold high-frequency stimuli, at different frequencies, were applied between two suprathreshold pulses S1 and S2. Our results show that when the TSc frequencies increases the ERP is elevated. The results also suggest that the delaying of recovery from inactivation of the fast INa current may be partially responsible for the ERP prolongation.",
author = "J. Saiz and Ferrero, {J. M.} and J. Chorro and M. Monserrat and V. Torres and Ferrero, {J. M.} and Thakor, {Nitish V}",
year = "1997",
language = "English (US)",
pages = "709--712",
booktitle = "Computers in Cardiology",
publisher = "IEEE Comp Soc",

}

TY - GEN

T1 - Prolongation of refractoriness by trains of subthreshold high-frequency stimuli

T2 - A simulation study

AU - Saiz, J.

AU - Ferrero, J. M.

AU - Chorro, J.

AU - Monserrat, M.

AU - Torres, V.

AU - Ferrero, J. M.

AU - Thakor, Nitish V

PY - 1997

Y1 - 1997

N2 - The effect of subthreshold high-frequency stimuli (TSc) on the prolongation of the refractory period (ERP) was studied using a computer model of a segment of ventricular tissue. The electrical behavior of each cell has been simulated using the Luo and Rudy phase II model. Trains of subthreshold high-frequency stimuli, at different frequencies, were applied between two suprathreshold pulses S1 and S2. Our results show that when the TSc frequencies increases the ERP is elevated. The results also suggest that the delaying of recovery from inactivation of the fast INa current may be partially responsible for the ERP prolongation.

AB - The effect of subthreshold high-frequency stimuli (TSc) on the prolongation of the refractory period (ERP) was studied using a computer model of a segment of ventricular tissue. The electrical behavior of each cell has been simulated using the Luo and Rudy phase II model. Trains of subthreshold high-frequency stimuli, at different frequencies, were applied between two suprathreshold pulses S1 and S2. Our results show that when the TSc frequencies increases the ERP is elevated. The results also suggest that the delaying of recovery from inactivation of the fast INa current may be partially responsible for the ERP prolongation.

UR - http://www.scopus.com/inward/record.url?scp=0031337291&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031337291&partnerID=8YFLogxK

M3 - Conference contribution

SP - 709

EP - 712

BT - Computers in Cardiology

PB - IEEE Comp Soc

ER -