Prolongation of refractoriness by trains of subthreshold high-frequency stimuli: A simulation study

J. Saiz, J. M. Ferrero, J. Chorro, M. Monserrat, V. Torres, J. M. Ferrero, N. V. Thakor

Research output: Contribution to journalConference article

Abstract

The effect of subthreshold high-frequency stimuli (TSc) on the prolongation of the refractory period (ERP) was studied using a computer model of a segment of ventricular tissue. The electrical behavior of each cell has been simulated using the Luo and Rudy phase II model. Trains of subthreshold high-frequency stimuli, at different frequencies, were applied between two suprathreshold pulses S1 and S2. Our results show that when the TSc frequencies increases the ERP is elevated. The results also suggest that the delaying of recovery from inactivation of the fast INa current may be partially responsible for the ERP prolongation.

Original languageEnglish (US)
Pages (from-to)709-712
Number of pages4
JournalComputers in cardiology
StatePublished - Dec 1 1997
EventProceedings of the 1997 24th Annual Meeting on Computers in Cardiology - Lund, Sweden
Duration: Sep 7 1997Sep 10 1997

ASJC Scopus subject areas

  • Computer Science Applications
  • Cardiology and Cardiovascular Medicine

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    Saiz, J., Ferrero, J. M., Chorro, J., Monserrat, M., Torres, V., Ferrero, J. M., & Thakor, N. V. (1997). Prolongation of refractoriness by trains of subthreshold high-frequency stimuli: A simulation study. Computers in cardiology, 709-712.