Prolongation of rat islet allograft survival by direct ultraviolet irradiation of the graft

Henry Lau, Keith Reemtsma, Mark A. Hardy

Research output: Contribution to journalArticlepeer-review

Abstract

Ultraviolet irradiation of rat dendritic cells completely abrogated their allostimulatory capacity in a mixed lymphocyte reaction. Rat islets of Langerhans similarly irradiated remained hormonally functional when transplanted into syngeneic diabetic rats. Allogeneic transplantation across a major histocompatibility barrier of islets initially treated in vitro with ultraviolet irradiation resulted in prolonged allograft survival without the use of any immunosuppressive agents.

Original languageEnglish (US)
Pages (from-to)607-609
Number of pages3
JournalScience
Volume223
Issue number4636
StatePublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • General

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