Abstract
Ultraviolet irradiation of rat dendritic cells completely abrogated their allostimulatory capacity in a mixed lymphocyte reaction. Rat islets of Langerhans similarly irradiated remained hormonally functional when transplanted into syngeneic diabetic rats. Allogeneic transplantation across a major histocompatibility barrier of islets initially treated in vitro with ultraviolet irradiation resulted in prolonged allograft survival without the use of any immunosuppressive agents.
Original language | English (US) |
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Pages (from-to) | 607-609 |
Number of pages | 3 |
Journal | Science |
Volume | 223 |
Issue number | 4636 |
State | Published - 1984 |
Externally published | Yes |
ASJC Scopus subject areas
- General