Proline inhibition of pyrroline-5-carboxylate reductase: Differences in enzymes obtained from animal and tissue culture sources

David Valle; Sylvia J. Downing; James M. Phang

doi:10.1016/0006-291X(73)91144-3

Proline inhibition of pyrroline-5-carboxylate reductase: Differences in enzymes obtained from animal and tissue culture sources

David Valle, Sylvia J. Downing, James M. Phang

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24 Scopus citations

Abstract

Pyrroline-5-carboxylate reductase obtained from several cell lines in culture has been shown to be approximately 50X more sensitive to proline inhibition than enzyme obtained from animal tissue sources. The description of this inhibition and possible causes for the difference between animal and tissue culture pyrroline-5-carboxylate reductase are presented.

Original language	English (US)
Pages (from-to)	1418-1424
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	54
Issue number	4
DOIs	https://doi.org/10.1016/0006-291X(73)91144-3
State	Published - Oct 15 1973
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/0006-291X(73)91144-3

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title = "Proline inhibition of pyrroline-5-carboxylate reductase: Differences in enzymes obtained from animal and tissue culture sources",

abstract = "Pyrroline-5-carboxylate reductase obtained from several cell lines in culture has been shown to be approximately 50X more sensitive to proline inhibition than enzyme obtained from animal tissue sources. The description of this inhibition and possible causes for the difference between animal and tissue culture pyrroline-5-carboxylate reductase are presented.",

author = "David Valle and Downing, {Sylvia J.} and Phang, {James M.}",

year = "1973",

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doi = "10.1016/0006-291X(73)91144-3",

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TY - JOUR

T1 - Proline inhibition of pyrroline-5-carboxylate reductase

T2 - Differences in enzymes obtained from animal and tissue culture sources

AU - Valle, David

AU - Downing, Sylvia J.

AU - Phang, James M.

PY - 1973/10/15

Y1 - 1973/10/15

N2 - Pyrroline-5-carboxylate reductase obtained from several cell lines in culture has been shown to be approximately 50X more sensitive to proline inhibition than enzyme obtained from animal tissue sources. The description of this inhibition and possible causes for the difference between animal and tissue culture pyrroline-5-carboxylate reductase are presented.

AB - Pyrroline-5-carboxylate reductase obtained from several cell lines in culture has been shown to be approximately 50X more sensitive to proline inhibition than enzyme obtained from animal tissue sources. The description of this inhibition and possible causes for the difference between animal and tissue culture pyrroline-5-carboxylate reductase are presented.

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U2 - 10.1016/0006-291X(73)91144-3

DO - 10.1016/0006-291X(73)91144-3

M3 - Article

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AN - SCOPUS:0015821563

SN - 0006-291X

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JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 4

ER -

Proline inhibition of pyrroline-5-carboxylate reductase: Differences in enzymes obtained from animal and tissue culture sources

Abstract

ASJC Scopus subject areas

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