Proline biosynthesis: Multiple defects in Chinese hamster ovary cells

David Valle, Sylvia J. Downing, Shirley C. Harris, James M. Phang

Research output: Contribution to journalArticlepeer-review


The biochemical basis for the proline requirement of Chinese hamster ovary cells has been investigated. The results indicate an absence of conversion of glutamate to proline and a 90% reduction in ornithine transaminase, the first enzyme in the pathway converting ornithine to proline. Possible explanations for this double defect are discussed.

Original languageEnglish (US)
Pages (from-to)1130-1136
Number of pages7
JournalBiochemical and Biophysical Research Communications
Issue number4
StatePublished - Aug 21 1973
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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