Proline biosynthesis: Multiple defects in Chinese hamster ovary cells

David Valle; Sylvia J. Downing; Shirley C. Harris; James M. Phang

doi:10.1016/0006-291X(73)90582-2

Proline biosynthesis: Multiple defects in Chinese hamster ovary cells

David Valle, Sylvia J. Downing, Shirley C. Harris, James M. Phang

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The biochemical basis for the proline requirement of Chinese hamster ovary cells has been investigated. The results indicate an absence of conversion of glutamate to proline and a 90% reduction in ornithine transaminase, the first enzyme in the pathway converting ornithine to proline. Possible explanations for this double defect are discussed.

Original language	English (US)
Pages (from-to)	1130-1136
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	53
Issue number	4
DOIs	https://doi.org/10.1016/0006-291X(73)90582-2
State	Published - Aug 21 1973
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/0006-291X(73)90582-2

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title = "Proline biosynthesis: Multiple defects in Chinese hamster ovary cells",

abstract = "The biochemical basis for the proline requirement of Chinese hamster ovary cells has been investigated. The results indicate an absence of conversion of glutamate to proline and a 90% reduction in ornithine transaminase, the first enzyme in the pathway converting ornithine to proline. Possible explanations for this double defect are discussed.",

author = "David Valle and Downing, {Sylvia J.} and Harris, {Shirley C.} and Phang, {James M.}",

year = "1973",

month = aug,

day = "21",

doi = "10.1016/0006-291X(73)90582-2",

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T2 - Multiple defects in Chinese hamster ovary cells

AU - Valle, David

AU - Downing, Sylvia J.

AU - Harris, Shirley C.

AU - Phang, James M.

PY - 1973/8/21

Y1 - 1973/8/21

N2 - The biochemical basis for the proline requirement of Chinese hamster ovary cells has been investigated. The results indicate an absence of conversion of glutamate to proline and a 90% reduction in ornithine transaminase, the first enzyme in the pathway converting ornithine to proline. Possible explanations for this double defect are discussed.

AB - The biochemical basis for the proline requirement of Chinese hamster ovary cells has been investigated. The results indicate an absence of conversion of glutamate to proline and a 90% reduction in ornithine transaminase, the first enzyme in the pathway converting ornithine to proline. Possible explanations for this double defect are discussed.

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U2 - 10.1016/0006-291X(73)90582-2

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AN - SCOPUS:0015908734

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JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 4

ER -

Proline biosynthesis: Multiple defects in Chinese hamster ovary cells

Abstract

ASJC Scopus subject areas

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