Proliferation accurately identifies the high-risk patients among small, low-grade, lymph node-negative invasive breast cancers

J. P A Baak, P. J. van Diest, E. A M Janssen, E. Gudlaugsson, F. J. Voorhorst, E. van der Wall, J. B. Vermorken

Research output: Contribution to journalArticle

Abstract

Background: The proliferation factor mitotic activity index (MAI) is the strongest prognosticator in lymph node-negative invasive breast cancer patients under age 71. The question remains, whether this also holds for 'favourable prognosis' subgroups. Patients and methods: The study was a multicentre prospective analysis of the MAI for recurrence-free survival and overall cancer-related survival of grade, MAI, and other prognosticators in 853 long-term follow-up, T1-3N0M0 breast cancer patients under 71 years. Results: In all tumours together (N = 853), in grade 3 (n = 269), in tumours

Original languageEnglish (US)
Pages (from-to)649-654
Number of pages6
JournalAnnals of Oncology
Volume19
Issue number4
DOIs
StatePublished - Apr 2008
Externally publishedYes

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Keywords

  • Breast cancer
  • Mitotic index
  • Prognosis
  • Proliferation
  • Small tumours
  • Well-differentiated cancers

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Baak, J. P. A., van Diest, P. J., Janssen, E. A. M., Gudlaugsson, E., Voorhorst, F. J., van der Wall, E., & Vermorken, J. B. (2008). Proliferation accurately identifies the high-risk patients among small, low-grade, lymph node-negative invasive breast cancers. Annals of Oncology, 19(4), 649-654. https://doi.org/10.1093/annonc/mdm535