Prolactin response to fenfluramine is independent of serotonin release

Una D. McCann, George Hatzidimitriou, George A. Ricaurte

Research output: Contribution to journalArticlepeer-review

Abstract

To assess the role of serotonin release in the prolactin response to fenfluramine, rats were treated with fenfluramine alone or in combination with a dose of fluoxetine known to block fenfluramine-induced serotonin release. Fluoxetine pretreatment did not prevent fenfluramine-induced increases in prolactin. These findings indicate that fenfluramine-induced increases in prolactin are independent of serotonin release, and possibly involve direct post-synaptic actions of fenfluramine or one of its metabolites (norfenfluramine).

Original languageEnglish (US)
Pages (from-to)R1-R2
JournalEuropean Journal of Pharmacology
Volume312
Issue number2
DOIs
StatePublished - Sep 26 1996

Keywords

  • 5-HT (5-hydroxytryptamine, serotonin)
  • Fluoxetine
  • Neuroendocrine challenge

ASJC Scopus subject areas

  • Pharmacology

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