TY - JOUR
T1 - Prolactin response to fenfluramine is independent of serotonin release
AU - McCann, Una D.
AU - Hatzidimitriou, George
AU - Ricaurte, George A.
N1 - Funding Information:
This work was supported by National Institutes of Health Grants PHS R01 DA06275 and K02 DA00206 to G.A.R., and by IRP support to U.D.M.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1996/9/26
Y1 - 1996/9/26
N2 - To assess the role of serotonin release in the prolactin response to fenfluramine, rats were treated with fenfluramine alone or in combination with a dose of fluoxetine known to block fenfluramine-induced serotonin release. Fluoxetine pretreatment did not prevent fenfluramine-induced increases in prolactin. These findings indicate that fenfluramine-induced increases in prolactin are independent of serotonin release, and possibly involve direct post-synaptic actions of fenfluramine or one of its metabolites (norfenfluramine).
AB - To assess the role of serotonin release in the prolactin response to fenfluramine, rats were treated with fenfluramine alone or in combination with a dose of fluoxetine known to block fenfluramine-induced serotonin release. Fluoxetine pretreatment did not prevent fenfluramine-induced increases in prolactin. These findings indicate that fenfluramine-induced increases in prolactin are independent of serotonin release, and possibly involve direct post-synaptic actions of fenfluramine or one of its metabolites (norfenfluramine).
KW - 5-HT (5-hydroxytryptamine, serotonin)
KW - Fluoxetine
KW - Neuroendocrine challenge
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U2 - 10.1016/0014-2999(96)00596-1
DO - 10.1016/0014-2999(96)00596-1
M3 - Article
C2 - 8894606
AN - SCOPUS:0030603241
VL - 312
SP - R1-R2
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 2
ER -