Prolactin prevents acute stress-induced hypocalcemia and ulcerogenesis by acting in the brain of rat

Takahiko Fujikawa, Hideaki Soya, Kellie Tamashiro, Randall R. Sakai, Bruce S. McEwen, Naoya Nakai, Masato Ogata, Ikukatsu Suzuki, Kunio Nakashima

Research output: Contribution to journalArticle

Abstract

Stress causes hypocalcemia and ulcerogenesis in rats. In rats under stressful conditions, a rapid and transient increase in circulating prolactin (PRL) is observed, and this enhanced PRL induces PRL receptors (PRLR) in the choroid plexus of rat brain. In this study we used restraint stress in water to elucidate the mechanism by which PRLR in the rat brain mediate the protective effect of PRL against stress-induced hypocalcemia and ulcerogenesis. We show that rat PRL acts through the long form of PRLR in the hypothalamus. This is followed by an increase in the long form of PRLR mRNA expression in the choroid plexus of the brain, which provides protection against restraint stress in water-induced hypocalcemia and gastric erosions. We also show that PRL induces the expression of PRLR protein and corticotropin-releasing factor mRNA in the paraventricular nucleus. These results suggest that the PRL levels increase in response to stress, and it moves from the circulation to the cerebrospinal fluid to act on the central nervous system and thereby plays an important role in helping to protect against acute stress-induced hypocalcemia and gastric erosions.

Original languageEnglish (US)
Pages (from-to)2006-2013
Number of pages8
JournalEndocrinology
Volume145
Issue number4
DOIs
StatePublished - Apr 2004
Externally publishedYes

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Hypocalcemia
Prolactin Receptors
Prolactin
Brain
Choroid Plexus
Dehydration
Stomach
Messenger RNA
Paraventricular Hypothalamic Nucleus
Corticotropin-Releasing Hormone
Hypothalamus
Cerebrospinal Fluid
Central Nervous System
Proteins

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Fujikawa, T., Soya, H., Tamashiro, K., Sakai, R. R., McEwen, B. S., Nakai, N., ... Nakashima, K. (2004). Prolactin prevents acute stress-induced hypocalcemia and ulcerogenesis by acting in the brain of rat. Endocrinology, 145(4), 2006-2013. https://doi.org/10.1210/en.2003-1446

Prolactin prevents acute stress-induced hypocalcemia and ulcerogenesis by acting in the brain of rat. / Fujikawa, Takahiko; Soya, Hideaki; Tamashiro, Kellie; Sakai, Randall R.; McEwen, Bruce S.; Nakai, Naoya; Ogata, Masato; Suzuki, Ikukatsu; Nakashima, Kunio.

In: Endocrinology, Vol. 145, No. 4, 04.2004, p. 2006-2013.

Research output: Contribution to journalArticle

Fujikawa, T, Soya, H, Tamashiro, K, Sakai, RR, McEwen, BS, Nakai, N, Ogata, M, Suzuki, I & Nakashima, K 2004, 'Prolactin prevents acute stress-induced hypocalcemia and ulcerogenesis by acting in the brain of rat', Endocrinology, vol. 145, no. 4, pp. 2006-2013. https://doi.org/10.1210/en.2003-1446
Fujikawa, Takahiko ; Soya, Hideaki ; Tamashiro, Kellie ; Sakai, Randall R. ; McEwen, Bruce S. ; Nakai, Naoya ; Ogata, Masato ; Suzuki, Ikukatsu ; Nakashima, Kunio. / Prolactin prevents acute stress-induced hypocalcemia and ulcerogenesis by acting in the brain of rat. In: Endocrinology. 2004 ; Vol. 145, No. 4. pp. 2006-2013.
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