Prolactin increases the density of striatal dopamine receptors in normal and hypophysectomized male rats

Robert E. Hruska, Karen T. Pitman, Ellen K. Silbergeld, Lynn M. Ludmer

Research output: Contribution to journalArticle

Abstract

Administration of prolactin to adult male rats, by s.c. injection, significantly increases the density of the striatal dopamine (DA) receptors, without altering the apparent affinity of the receptors for [3H]spiroperidol. Larger doses of prolactin are required to increase the density of the striatal DA receptors in hypophysectomized rates compared to normal rats. These results suggest that prolactin might be the common mediator of the increase in striatal DA receptor density produced by either estrogen or haloperidol administration. Monitoring and/or altering prolactin levels might be informative in neurologic or psychiatric disorders involving striatal DA neurotransmission.

Original languageEnglish (US)
Pages (from-to)547-553
Number of pages7
JournalLife Sciences
Volume30
Issue number6
DOIs
StatePublished - Feb 7 1982
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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