Projecting the impact of implementing pre-exposure prophylaxis for HIV among men who have sex with men in Baltimore city

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Men who have sex with men (MSM) experience over half of new HIV infections annually in Baltimore city. Oral pre-exposure prophylaxis (PrEP) and antiretroviral therapy (ART) are likely to play central roles in reducing the risk of HIV transmission. However, the likely combined impact of these interventions remains uncertain. We propose an individual-based simulation approach to project the population-level impact of implementing PrEP for high-risk MSM in Baltimore, with different levels of coverage and adherence. The primary outcome is the HIV incidence over five years. We project non-linear relationships between program coverage, individual-level adherence, and population-level impact. The impact of PrEP increases with time but is not sustained if PrEP provision ceases. Expansion of ART coverage can augment the impact of PrEP on HIV incidence over the next decade.

Original languageEnglish (US)
Title of host publication2015 Winter Simulation Conference, WSC 2015
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages3140-3141
Number of pages2
ISBN (Electronic)9781467397438
DOIs
StatePublished - Feb 16 2016
EventWinter Simulation Conference, WSC 2015 - Huntington Beach, United States
Duration: Dec 6 2015Dec 9 2015

Publication series

NameProceedings - Winter Simulation Conference
Volume2016-February
ISSN (Print)0891-7736

Other

OtherWinter Simulation Conference, WSC 2015
CountryUnited States
CityHuntington Beach
Period12/6/1512/9/15

ASJC Scopus subject areas

  • Software
  • Modeling and Simulation
  • Computer Science Applications

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