TY - JOUR
T1 - Progressive failure of coronary flow during reperfusion of myocardial infarction
T2 - Documentation of the no reflow phenomenon with positron emission tomography
AU - Jeremy, Richmond W.
AU - Links, Jonathan M.
AU - Becker, Lewis C.
PY - 1990/9
Y1 - 1990/9
N2 - During reperfusion of a myocardial infarct, development of microvascular occlusion may result in regional hypoperfusion ("no reflow") despite a patent infarct-related artery. This study examined the extent and time course of no reflow with use of rubidium-82 positron emission tomography. In 12 anesthetized dogs, the left anterior coronary artery was occluded for 90 min and then freely reperfused. Regional myocardial perfusions was imaged by serial rabidium-82 positron emission tomography during coronary occlusion and every 30 min during reperfusion. After 4 h of reperfusion, infarct size and no reflow zone were measured postmortem by triphenyltetrazolium and thioflavin staining, respectively. Perfusion defects evident on rubidium-82 images during coronary occlusion rapidly resolved during the early reflow period. However, a recurrent perfusion defect appeared after 1 to 2 h of reflow in all dogs. The severity of recurrent perfusion defects progressed with time; after 5 min of reflow, relative perfusion in the left anterior descending artery territory was 97 ± 6% of that in the normal circumflex artery region, but perfusion decreased progressively to 68 ± 5% after 2 h (p < 0.05) and to 55 ± 4% after 4 h of reperfusion (p < 0.05 versus 2 h). As measured by radioactive tracer microspheres, endocardial blood flow decreased similarly in the postischemic left anterior descending artery region from 1.2 ± 0.2 ml/mim per g after 5 min of reflow to 0.4 ± 0.1 ml/min per g after 3 h of reflow (p < 0.01). Residual infarct perfusion, measured by rabidium-82 after 4 h of reflow, was related to both infarct size (r = -0.88) and the extent of the no reflow zone (r = -0.84) in the postmortem left ventricular sections. Thus, serial positron emission tomography with rabidium-82 demonstrates a progressive loss of infarct perfusion, beginning 1 to 2 h after initial restoration of blood flow despite patency of the infarct-related artery. This phenomenon is probably a manifestation of progressive microvascular occlusion within the reperfused myocardium.
AB - During reperfusion of a myocardial infarct, development of microvascular occlusion may result in regional hypoperfusion ("no reflow") despite a patent infarct-related artery. This study examined the extent and time course of no reflow with use of rubidium-82 positron emission tomography. In 12 anesthetized dogs, the left anterior coronary artery was occluded for 90 min and then freely reperfused. Regional myocardial perfusions was imaged by serial rabidium-82 positron emission tomography during coronary occlusion and every 30 min during reperfusion. After 4 h of reperfusion, infarct size and no reflow zone were measured postmortem by triphenyltetrazolium and thioflavin staining, respectively. Perfusion defects evident on rubidium-82 images during coronary occlusion rapidly resolved during the early reflow period. However, a recurrent perfusion defect appeared after 1 to 2 h of reflow in all dogs. The severity of recurrent perfusion defects progressed with time; after 5 min of reflow, relative perfusion in the left anterior descending artery territory was 97 ± 6% of that in the normal circumflex artery region, but perfusion decreased progressively to 68 ± 5% after 2 h (p < 0.05) and to 55 ± 4% after 4 h of reperfusion (p < 0.05 versus 2 h). As measured by radioactive tracer microspheres, endocardial blood flow decreased similarly in the postischemic left anterior descending artery region from 1.2 ± 0.2 ml/mim per g after 5 min of reflow to 0.4 ± 0.1 ml/min per g after 3 h of reflow (p < 0.01). Residual infarct perfusion, measured by rabidium-82 after 4 h of reflow, was related to both infarct size (r = -0.88) and the extent of the no reflow zone (r = -0.84) in the postmortem left ventricular sections. Thus, serial positron emission tomography with rabidium-82 demonstrates a progressive loss of infarct perfusion, beginning 1 to 2 h after initial restoration of blood flow despite patency of the infarct-related artery. This phenomenon is probably a manifestation of progressive microvascular occlusion within the reperfused myocardium.
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U2 - 10.1016/0735-1097(90)90362-S
DO - 10.1016/0735-1097(90)90362-S
M3 - Article
C2 - 2387943
AN - SCOPUS:0024992171
SN - 0735-1097
VL - 16
SP - 695
EP - 704
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 3
ER -