Progressive catatonia

James R Brasic, David Zagzag, S. Kowalik, Leslie Prichep, E. Roy John, Howard G. Liang, Bruce Klutchko, Robert Cancro, Brian Barry Sheitman, Monte Buchsbaum, Carla Brathwaite

Research output: Contribution to journalArticle

Abstract

We present the case of a young man with a diagnosis of a childhood-onset pervasive developmental disorder who developed a progressive neurologic deterioration with persistent catatonia and right hemiparesis. On his initial evaluation approximately three years after the onset of mutism, he manifested right hemiparesis and catalepsy. Two years later, although catalepsy had subsided, motor function had deteriorated so that he could not use his hands to feed or dress himself. Oral-facial-buccal dyskinesia manifested by blepharospasm and grimacing were present constantly during waking hours. Quantitative electroencephalography demonstrated markedly decreased amplitude, a finding associated with catatonia. Left sural nerve biopsy indicated large axon cylinder degeneration. Left deltoid biopsy demonstrated perimysial fibrosis and type II fiber predominance. Although magnetic resonance imaging of the head without contrast was normal, positron emission tomography indicated hypometabolism of the right cerebral and the right cerebellar hemispheres. The patient continues to deteriorate despite a course of 25 electroconvulsive treatments. He continues to manifest criteria for catatonia including motoric immobility, mutism, and peculiarities of voluntary movement such as prominent grimacing. We suspect an inherited neurodegenerative disorder. Since catatonia is a treatable condition frequently associated with medical and neurological diseases, examination for the features of catatonia must be included in the assessment of patients with progressive brain degeneration. This report is an attempt to clarify the traits of a serious variant of progressive brain degeneration.

Original languageEnglish (US)
Pages (from-to)239-246
Number of pages8
JournalPsychological Reports
Volume84
Issue number1
StatePublished - Feb 1999
Externally publishedYes

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Catatonia
Mutism
Catalepsy
Paresis
Blepharospasm
Biopsy
Sural Nerve
Cheek
Dyskinesias
Neurologic Examination
Brain
Cerebrum
Neurodegenerative Diseases
Positron-Emission Tomography
Nervous System
Axons
Electroencephalography
Fibrosis
Hand
Head

ASJC Scopus subject areas

  • Psychology(all)

Cite this

Brasic, J. R., Zagzag, D., Kowalik, S., Prichep, L., John, E. R., Liang, H. G., ... Brathwaite, C. (1999). Progressive catatonia. Psychological Reports, 84(1), 239-246.

Progressive catatonia. / Brasic, James R; Zagzag, David; Kowalik, S.; Prichep, Leslie; John, E. Roy; Liang, Howard G.; Klutchko, Bruce; Cancro, Robert; Sheitman, Brian Barry; Buchsbaum, Monte; Brathwaite, Carla.

In: Psychological Reports, Vol. 84, No. 1, 02.1999, p. 239-246.

Research output: Contribution to journalArticle

Brasic, JR, Zagzag, D, Kowalik, S, Prichep, L, John, ER, Liang, HG, Klutchko, B, Cancro, R, Sheitman, BB, Buchsbaum, M & Brathwaite, C 1999, 'Progressive catatonia', Psychological Reports, vol. 84, no. 1, pp. 239-246.
Brasic JR, Zagzag D, Kowalik S, Prichep L, John ER, Liang HG et al. Progressive catatonia. Psychological Reports. 1999 Feb;84(1):239-246.
Brasic, James R ; Zagzag, David ; Kowalik, S. ; Prichep, Leslie ; John, E. Roy ; Liang, Howard G. ; Klutchko, Bruce ; Cancro, Robert ; Sheitman, Brian Barry ; Buchsbaum, Monte ; Brathwaite, Carla. / Progressive catatonia. In: Psychological Reports. 1999 ; Vol. 84, No. 1. pp. 239-246.
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