TY - JOUR
T1 - Progressive caloric restriction induces dose-dependent changes in myocardial triglyceride content and diastolic function in healthy men
AU - Hammer, Sebastiaan
AU - Van Der Meer, Rutger W.
AU - Lamb, Hildo J.
AU - Schär, Michael
AU - De Roos, Albert
AU - Smit, Jan W.A.
AU - Romijn, Johannes A.
PY - 2008/2
Y1 - 2008/2
N2 - Context: In animal experiments, high plasma concentrations of free fatty acids (FFAs) are associated with increased triglyceride (TG) stores in liver and heart, and impaired cardiac function. In humans caloric restriction increases plasma FFA levels. Objective: Our objective was to assess the effects of progressive caloric restriction on myocardial and hepatic TG content and myocardial function. Design: This was a prospective intervention study. Participants: This study included 10 lean healthy men. Interventions: Three-day partial (471 kcal/d) and complete starvation was performed. Outcome Measures: Plasma levels of FFA, myocardial and hepatic TG content, and myocardial function were calculated. Results: Plasma FFA increased from 0.6 ± 0.4 mmol/liter to 1.2 ± 0.4 and to 1.9 ± 0.7 mmol/liter, after partial and complete starvation, respectively (P < 0.001). Myocardial TG content increased from 0.35 ± 0.14% to 0.59 ± 0.27%, and 1.26 ± 0.49%, respectively (P < 0.01). The ratio between the early diastole and atrial contraction decreased from 2.2 ± 0.4 to 2.1 ± 0.4 (P = 0.7) and 1.8 ± 0.4, respectively (P < 0.01), and diastolic early deceleration from 3.4 ± 0.7 ml/sec2 × 10-3 to 2.9 ± 0.5 and 2.8 ± 0.9 ml/sec2 × 10 -3, respectively (P < 0.05). Hepatic TG content decreased after partial starvation (from 2.23 ± 2.24% to 1.43 ± 1.33%; P < 0.05) but did not change upon complete starvation. Conclusions: Progressive caloric restriction induces a dose-dependent increase in myocardial TG content and a dose-dependent decrease in diastolic function in lean healthy men. Hepatic TG content showed a differential response to progressive caloric restriction, indicating that redistribution of endogenous TG stores is tissue specific.
AB - Context: In animal experiments, high plasma concentrations of free fatty acids (FFAs) are associated with increased triglyceride (TG) stores in liver and heart, and impaired cardiac function. In humans caloric restriction increases plasma FFA levels. Objective: Our objective was to assess the effects of progressive caloric restriction on myocardial and hepatic TG content and myocardial function. Design: This was a prospective intervention study. Participants: This study included 10 lean healthy men. Interventions: Three-day partial (471 kcal/d) and complete starvation was performed. Outcome Measures: Plasma levels of FFA, myocardial and hepatic TG content, and myocardial function were calculated. Results: Plasma FFA increased from 0.6 ± 0.4 mmol/liter to 1.2 ± 0.4 and to 1.9 ± 0.7 mmol/liter, after partial and complete starvation, respectively (P < 0.001). Myocardial TG content increased from 0.35 ± 0.14% to 0.59 ± 0.27%, and 1.26 ± 0.49%, respectively (P < 0.01). The ratio between the early diastole and atrial contraction decreased from 2.2 ± 0.4 to 2.1 ± 0.4 (P = 0.7) and 1.8 ± 0.4, respectively (P < 0.01), and diastolic early deceleration from 3.4 ± 0.7 ml/sec2 × 10-3 to 2.9 ± 0.5 and 2.8 ± 0.9 ml/sec2 × 10 -3, respectively (P < 0.05). Hepatic TG content decreased after partial starvation (from 2.23 ± 2.24% to 1.43 ± 1.33%; P < 0.05) but did not change upon complete starvation. Conclusions: Progressive caloric restriction induces a dose-dependent increase in myocardial TG content and a dose-dependent decrease in diastolic function in lean healthy men. Hepatic TG content showed a differential response to progressive caloric restriction, indicating that redistribution of endogenous TG stores is tissue specific.
UR - http://www.scopus.com/inward/record.url?scp=39049116617&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=39049116617&partnerID=8YFLogxK
U2 - 10.1210/jc.2007-2015
DO - 10.1210/jc.2007-2015
M3 - Article
C2 - 18029455
AN - SCOPUS:39049116617
SN - 0021-972X
VL - 93
SP - 497
EP - 503
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 2
ER -